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Coronavirus that causes COVID-19 is detected in tears sampled by ocular swabs, stated a new study. The researchers analyzed samples from patients diagnosed with the disease by conventional methods and admitted to the Hospital, according to the study published in the Journal of Clinical Medicine. Presence of COVID-19 Virus in Tears "Initially, we set out to develop a diagnostic test based on an easier collection of material without causing patient discomfort. Nasal and nasopharyngeal [...]

Researchers examined the processes that cause side effects of two drugs (paclitaxel and immune checkpoint inhibitors anti-PD1 and anti-PDL1) used in combination to combat lung and breast cancer. A combination of chemotherapy and drugs that stimulate the immune system to combat cancer is increasingly used to control progression of the disease in patients. On the other hand, clinical studies show that the combination has adverse side effects, such as peripheral neuropathy characterized by [...]

Highlights: Children’s anti-inflammatory medications can cause changes to their teeth’ enamel NSAIDs like Celecoxib and Indomethacin can interfere with the development of the enamel and cause dental enamel abnormalities which are similar to the effect of tetracycline on developing teeth An appropriate protocol needs to be developed to regulate these over-the-counter drugs to avoid such side effects among youngsters A study undertaken at the University of São [...]

The proportion of the population previously infected by SARS-CoV-2 (infection-induced seroprevalence) can be estimated using blood donation samples, according to a new study published in the journal eLife. The findings offer a sort of portrait of the first year of the COVID-19 epidemic in Brazil. The usual method of estimating seroprevalence in Brazil is based on random samples of the population. This method is costly and hard to perform periodically in real-time. Serosurveillance is [...]

Fetal exposure to antidepressant drugs, especially sertraline, the most prescribed antidepressant worldwide has been explored by a review study of more than 100 scientific articles by Brazilian researchers at the Fundação De Amparo À Pesquisa Do Estado De São Paulo. Depression affects 10%-16% of pregnant women worldwide. Most get better with the help of antidepressant drugs. Depression is common during pregnancy and antidepressants are usually prescribed to [...]

Human genetic factors may contribute to the extremely high transmissibility of SARS-CoV-2. COVID-19 severity among the elderly may be related to immunosenescence, changes in cytokine patterns, activation of inflammatory pathways, and impaired innate and adaptive immune responses. Two recent papers by Brazilian researchers have contributed to the scientific understanding of the genetic factors that protect people against infection by SARS-CoV-2 or prevent progression to severe [...]

Another co-author is Gustavo Gastão Davanzo, a PhD candidate at IB-UNICAMP with a scholarship from FAPESP. "These are very expensive treatments, but we believe it could be a viable option because there aren't as many critical patients as there were at the start of the pandemic, provided further research confirms that it's safe for COVID-19 patients," Moraes-Vieira said. Murine Coronavirus The hypothesis tested in the study arose when Uruguayan researchers [...]

In COVID-19 patients, niclosamide, the anti-helmintic drug inhibits SARS-CoV-2 replication as well as the exacerbated inflammatory response that leads to death. More research is needed to find out whether the effects, described in an article published in Science Advances, are confirmed in patients with the disease, and according to the authors this will require the development of a novel formulation of the drug, as the one currently available from pharmacies is orally administered and would [...]

The molecular mechanisms that explain microcephaly in babies born to mothers infected by zika virus have been discovered by researchers. The research proposes a model at the molecular level to understand the complications caused by infection during pregnancy and paves the way to the identification of novel therapeutic targets. Potential Mechanisms of Zika‐linked Microcephaly According to an article on the study published in Molecular Neurobiology, the researchers conducted a [...]