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A new mechanism discovered by scientists helps explain how certain kinds of genetic disorders known as mitochondrial diseases are transmitted from mother to child. The study it reports could serve as the basis for novel strategies to ensure that future generations are not affected by such diseases. Existing treatments are palliative, aimed at improving quality of life for the patient or delaying progression of the disease. ‘The study could serve as the basis for novel strategies to [...]

Omicron emerged as a variant of concern only in November 2021, but all the mutations it contains except one had been described before that. Researchers at the Federal University of São Paulo (UNIFESP) in Brazil, supported by FAPESP, attribute this factor to the effectiveness of the existing vaccines against the variant, reflected in the relatively small number of severe cases and deaths despite omicron's heightened transmissibility. This hypothesis has been raised in an [...]

Treatment with house dust mite extract is effective against all signs and symptoms of atopic dermatitis (eczema), as per the team of researchers at the University of São Paulo's Ribeirao Preto Medical School (FMRP-USP) in Brazil. Researchers studied the effects of sublingual immunotherapy with extract of Dermatophagoides pteronyssinus, a ubiquitous dust mite, administered to patients in drops for 18 months. Dust mites are microscopic arachnids that live in house dust and feed [...]

Prophylactic administration did not prove beneficial in the randomized clinical trial described in the article. The study involved 465 patients treated at 28 hospitals in six countries, including Brazil. “We believe these results should change clinical practice,” Elnara Negri, a co-author of the article, told Agencia FAPESP. Negri is a professor and physician at So Paulo’s Syrian-Lebanese Hospital and Hospital das Clnicas (HC), the hospital complex run by the University of So [...]

Liver transplanted patients who acquired COVID-19 recovered faster without serious inflammation while compared to the kidney and heart transplant recipients, moreover, some of the liver transplanted patients did even better than the non-transplant patients, finds a study conducted at Hospital das Clínicas (HC), the hospital complex run by the University of São Paulo's Medical School (FM-USP) in Brazil. A study published in the journal Transplantology reports that the [...]

Benefits of aerobic exercise on the gait of Parkinson's patients can be enhanced immediately after a session of transcranial direct current stimulation (tDCS), as per a study at the São Paulo State University's Institute of Biosciences (IB-UNESP) in Rio Claro, Brazil, published in Neurorehabilitation & Neural Repair. Parkinson's disease (PD) is a progressive neurodegenerative disorder that primarily affects movement due to loss of nerve cells - neurons that produce a [...]

Curcumin, an active component of turmeric (Curcuma longa), associated with photodynamic therapy can help reduce the parasite load and eliminate Leishmania parasites completely, reveals a new study reported in the journal Antibiotics. The findings point the way to future research in humans in pursuit of more effective treatment of the disease. The authors are researchers at the University of Paraiba Valley (UNIVAP) in São José dos Campos, São Paulo State [...]

Genosensors are inexpensive biosensors that help in rapid diagnosis of viruses. Based on nucleic acids that detect simple complementary DNA or RNA sequences, genosensors make possible mass testing for immediate and sensitive testing of genetic material. This device is produced in Brazil by various researchers and led by physicist Osvaldo Novais de Oliveira Junior, a professor at the University of São Paulo's São Carlos Institute of Physics (IFSC-USP). Diagnosis can be made [...]

SARS-CoV-2 is considered a deadly virus that affects the respiratory tract. Researchers from the University of São Paulo now suggest that the virus can also grow and multiply on the cells of salivary glands. A previous study found that salivary glands contain ACE-2 receptors, on which the spike proteins of SARS-CoV-2 stick themselves and attach to our body cells. In addition to this, many animal studies have proved the presence of receptors such as transmembrane serine protease 2 [...]