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Researchers have identified a genetic signature with prognostic value for certain kinds of breast cancer. The discovery also contributes to a better understanding of the molecular mechanisms of pathological angiogenesis, the aberrant proliferation of blood vessels that occurs during cancer and other diseases. The research, published in the journal PLOS Genetics, combined a study of the genes involved in retinopathy, as a model of angiogenesis, with analysis of transcriptomic gene expression [...]

Using an experimental model of multiple sclerosis, the scientists found that the sympathetic nervous system can limit the generation of effector responses by inhibiting the action of the cells that attack an antigen taken as a threat by the immune system The results of a study conducted in Brazil suggest that the sympathetic nervous system – the part of the autonomous nervous system that controls responses to danger or stress – can modulate the action of defense cells in patients [...]

The mechanism by which defense cells respond to infection by the Mayaro virus has been described by a team affiliated with the Center for Research on Inflammatory Diseases (CRID) in an article published in the journal PLOS Pathogens. According to the authors, by establishing an experimental model of Mayaro fever in adult mice and identifying the processes involved in the immune response, the study provides a basis for the development of drugs against this disease. CRID is one of the Research, [...]

Researchers from the University of São Paulo (USP) in Brazil have developed a strategy for treating the most aggressive type of brain cancer in adults that combines a photoactive molecule and a chemotherapeutic agent—both encapsulated in protein-lipid nanoparticles. Results of the research, supported by São Paulo Research Foundation—FAPESP, were presented during the FAPESP Week France symposium, by Antônio Claudio Tedesco, of the Center for Nanotechnology, [...]

More than half the world's population runs the risk of contracting infectious diseases transmitted by mosquitoes in the next few years. With climate change, these so-called arboviruses—once a problem concentrated in the planet's tropical regions—appear to also be occurring in places with a temperate climate. "Recent studies indicate that the bacteria present in the intestine of vector mosquitoes contribute to the adaptive potential of these insects. It is [...]

Research suggests that bacteria present in the intestine of the Anhopheles darlingi mosquito influence the development of the parasite that causes the disease in the insect’s body and the chances of transmission to humans The bacteria that form the gut microbiota influence important processes of the human body, such as digestion, nutrient absorption, and defense against pathogens. The same type of relationship is present in most animals, including in the Anhopheles darlingi mosquito, the [...]

A study by Brazilian researchers suggests that cardiac overload due to the stress of driving in heavy traffic can be attenuated by listening to instrumental music.  Stress while driving is a risk factor for the development of cardiovascular disease and sudden cardiac complications such as heart attack (myocardial infarction), according to studies published in recent years. Selecting suitable driving music may be one way to mitigate this risk. A study by researchers at São Paulo [...]

In Brazil, scientists affiliated with the Human Genome and Stem Cell Research Center (HUG-CELL) at the University of São Paulo (USP) have identified a molecule capable of reducing the aggressiveness of embryonal central nervous system tumors. These are malignant tumors that start in fetal cells in the brain and mainly affect children up to four years old. The results are published in the journal Molecular Oncology. HUG-CELL is one of the Research, Innovation and Dissemination Centers [...]

Thanks to a new injectable formula, Brazilian researchers have succeeded in enhancing the efficacy and prolonging the duration of action of a drug commonly used to treat joint inflammation. The innovation involves lipid nanoparticles containing a high concentration of the active principle, which is gradually released into the affected joint to sustain the desired effect for up to ten days without the need for repeated administration of the drug. In an article published in the journal [...]