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VmCT1, the antimicrobial peptide isolated from the venom of the scorpion Vaejovis mexicanus killed Trypanosoma cruzi, the parasite that causes Chagas disease, said researchers at the Federal University of the ABC (UFABC), Federal University of São Paulo (UNIFESP) and Federal University of Ceará (UFC) in Brazil. Previous research has demonstrated VmCT1's potential against Gram-positive and Gram-negative bacteria, as well as tumor cells and other protozoans. "VmCT1 [...]

Adipose tissue is a layer of tissue present beneath the skin of humans. This tissue is a simple reservoir of energy during the need and contributes significantly to the regulation of metabolism. The adipose tissue is involved in releasing various molecules into the bloodstream, including microRNAs that modulate the expression of key genes in different parts of the organism, including the liver, pancreas, and muscles. The regulation of the microRNAs by adipose tissue is affected by aging and [...]

Drug used to treat bacterial infections could increase the metabolism and down the weight gain induced by a fatty diet in mice, according to the study conducted at the University of Campinas (UNICAMP) with FAPESP's support. The findings have just been published in the journal Science Advances. According to Marcelo Mori, a professor at the university's Biology Institute (IB-UNICAMP) and principal investigator for the project, the treatment made the animals' white adipose tissue, [...]

Novel transparent, stretchable plastic (PVC) film used to package fruits, meats and other foods to protect surfaces could inactivate the novel coronavirus responsible for the COVID-19 outbreak worldwide. The material contains silver and silica nanoparticles marketed by Brazilian plastics manufacturer Alpes, a technology developed and licensed by Nanox. University of Sao Paulo's Biomedical Sciences Institute (ICB-USP) conducted the test. The PVC film showed capable of killing 79.9 percent [...]

Muscle regeneration promoted by aerobic exercise is mediated by changes in oxygen consumption by satellite cells, said University of São Paulo (USP) researchers. The satellite cells are known as skeletal muscle stem cells. The new discovery is expected to be used to help people recover from injury and combat the loss of muscle mass associated with aging. Previous research showed that weight lifting and other kinds of strength training increase the number of satellite cells. In aerobic [...]

Irisin, commonly known as the exercise hormone could have a therapeutic effect on COVID-19 patients, said São Paulo State University (UNESP) researchers. The findings of the study are published in Molecular and Cellular Endocrinology. "We compared data for genes important in COVID-19 with our transcriptomic data to make correlations. The results offer a clue in the search for treatment of the disease during the emergency caused by the pandemic. It must be stressed that our findings [...]

Freezing of gait, one of the most disabling symptoms of Parkinson's disease, manifests as sudden, short episodes of an inability to move the feet forward despite the intention to walk. Brazilian researchers use complex training program to activate different motor and cognitive skills simultaneously and restore brain regions associated with freezing of gait in advanced-stage patients. Researchers at the University of São Paulo (USP) in Brazil have shown that the disorder can be [...]

Zika virus infection during pregnancy results in severe abnormalities to the fetus. Brazilian researchers for the first time figure out what happens in the fetal brain when affected by congenital Zika syndrome (CZS) by using genomics, proteomics and transcriptomics data. A paper describing their findings has been published in the journal Science Signaling. "We show for the first time what happens in the fetal brain affected by congenital Zika syndrome [CZS]," Helder Nakaya, who is [...]

A sensor which is wearable is printed on microbial nanocellulose, a natural polymer, to detect and monitor body fluids in sweat. The sensor has been created in Brazil by researchers at the University of São Paulo (USP) in São Carlos in collaboration with colleagues at São Paulo State University (UNESP) in Araraquara, the University of Araraquara (UNIARA), the University of Campinas (UNICAMP), and the Brazilian National Nanotechnology Laboratory (LNNano). The skin-adherent [...]