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A set of fossils recovered in Rio Grande do Sul, Brazil's southernmost state, has brought an extra layer of complexity to the study of the evolutionary history of silesaurids, a family of dinosauriforms (dinosaurs and their close relatives) that lived in the Triassic period between 247 million and 208 million years ago. In an article published in the Journal of Vertebrate Paleontology, researchers affiliated with institutions in Brazil and the United States show that even with the new [...]

Rabies virus variants closely related to variants present in White-tufted marmosets (Callithrix jacchus) have been detected in bats in Ceará state, Northeast Brazil. Rabies is a deadly disease for humans. Its emergence in distinct wildlife species is a potential source of human infection and hence a public health concern. Marmosets are common in forests and conservation units throughout Brazil. In or near urban areas, they are often captured as pets and later abandoned. They have [...]

Lipids are a diversified class of biomolecules with a wide array of functions, from energy storage to regulation of fundamental cellular processes. Oxidized lipids have received considerable attention because of their association with oxidative stress, inflammation and cell signaling. Oxylipins, for example, are bioactive lipids generated by oxidation of polyunsaturated fatty acids (PUFAs) and have been associated with several neurodegenerative diseases. Amyotrophic lateral sclerosis (ALS) [...]

Washington DC [US], November 10 (ANI): Researchers at the University of Sao Paulo (USP) in Brazil, in collaboration with colleagues in Australia, discovered a unique bacterial protein that can maintain human cells healthy even when the cells are heavily contaminated with bacteria. The discovery could lead to new treatments for a wide range of mitochondrial dysfunction-related ailments, including cancer and auto-immune disorders. Mitochondria are organelles that provide the majority of the [...]

Researchers at the University of São Paulo (USP) in Brazil, partnering with colleagues in Australia, have identified a novel bacterial protein that can keep human cells healthy even when the cells have a heavy bacterial burden. The discovery could lead to new treatments for a wide array of diseases relating to mitochondrial dysfunction, such as cancer and auto-immune disorders. Mitochondria are organelles that supply most of the chemical energy needed to power cells' biochemical [...]

Researchers have discovered a previously unknown pathological cellular mechanism underpinning heart failure, which currently has no cure, and identified a drug that can reverse the damaging malfunction. The findings open the door to a novel intervention to improve outcomes in people with the condition. With an estimated prevalence of 64 million people worldwide, heart failure is a rapidly growing public health issue. Rather than being a specific disease, heart failure is a clinical syndrome [...]

Researchers at the University of São Paulo (USP) in Brazil, partnering with colleagues in Australia, have identified a novel bacterial protein that can keep human cells healthy even when the cells have a heavy bacterial burden. The discovery could lead to new treatments for a wide array of diseases relating to mitochondrial dysfunction, such as cancer and auto-immune disorders. Mitochondria are organelles that supply most of the chemical energy needed to power cells' biochemical [...]

Researchers at the University of São Paulo (USP) in Brazil, partnering with Foresee Pharmaceuticals, a Taiwan and US-based biopharmaceutical company, have tested a synthetic molecule for the treatment of heart failure. The study, funded by FAPESP, was published yesterday (11/07/2023) in the European Heart Journal. The theme was also highlighted in the magazine's editorial. Heart failure is a condition in which the heart muscle cannot pump enough blood to meet the body's needs [...]

The incidence of thyroid cancer in São Paulo State, part of Brazil's relatively developed Southeast region, varies considerably according to socioeconomic status (education, poverty, wealth, income, segregation, mobility, and access to resources and services) and access to screening, but is highest in higher-income areas and the state capital. Mortality rates are similar across regions and income groups, however. These are the main findings of a study reported in the journal [...]