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A drug originally developed to treat bacterial infections has proved capable of boosting the metabolism and attenuating the weight gain induced by a fatty diet in tests with mice. The study was conducted at the University of Campinas (UNICAMP) with FAPESP's support, and the findings have just been published in the journal Science Advances. According to Marcelo Mori, a professor at the university's Biology Institute (IB-UNICAMP) and principal investigator for the project, the treatment [...]

You might have observed plants competing for sunlight — the way they stretch upwards and outwards to block each other’s access to the sun’s rays — but out of sight, another type of competition is happening underground. In the same way that you might change the way you forage for free snacks in the break room when your colleagues are present, plants change their use of underground resources when they’re planted alongside other plants. In a paper published today in [...]

Accelerating tree growth in recent years has been accompanied by a reduction in tree lifespan, which could eventually neutralize part of the increase in net uptake of carbon dioxide (CO2). This trade-off between tree growth and life expectancy applies to forests worldwide, including in the Amazon and other tropical regions, as well as temperate regions and the Arctic. Models and projections of future forest carbon uptake based on the existing system may therefore overestimate the capacity of [...]

Anecdotal reports claim that the incidence of cancer in sharks is very low, but there is not enough data to confirm this estimate categorically. A study published in the journal Genomics, however, presents strong evidence of anti-tumor activity in the genome of the Shortfin mako shark, Isurus oxyrinchus. This large pelagic species, which can be as long as 4 meters, inhabits temperate and tropical seas worldwide. It is classified as endangered by IUCN, owing mainly to non-selective longline [...]

The onset of any physical exercise program causes muscle pain that can hinder movements as simple as getting up from a sofa. With time and a little persistence, the muscles become accustomed to the effort, developing more strength and endurance. Researchers affiliated with Harvard University in the United States and the University of São Paulo (USP) in Brazil describe the cellular mediator that makes this adaptation to exercise possible in the journal Cell. The mediator is succinate, a [...]

Researchers at the University of São Paulo (USP) in Brazil have demonstrated for the first time that in COVID-19 patients an immune mechanism known as the inflammasome participates in activation of the inflammatory process that can damage several organs and even lead to death. An article reporting the findings of the study, which was supported by FAPESP, has just been published in the Journal of Experimental Medicine. According to the authors, the findings support the use of [...]

Young Brazilians are increasingly interested in biodiversity, conservation of the Amazon and science as they begin high school, but school students in the North region are more interested in learning about these subjects, and about local fauna and flora, than their peers in the Southeast. These are some of the findings of a study reported in an article in Science Advances. Part of a Thematic Project supported by FAPESP (São Paulo Research Foundation), the study analyzed data from five [...]

The savanna tree frog Bokermannohyla ibitiguara is about 4 cm long and is found only in gallery forest along streams in the Serra da Canastra mountain range in the state of Minas Gerais, Southeast Brazil. In this watery forest environment, it can grow, feed, mate, and lay eggs without needing to range very far throughout its life cycle, according to a study published in Diversity and Distributions. According to the Brazilian and US researchers who conducted the study, topography rather than [...]

There is growing evidence that adipose tissue plays a key role in the aggravation of COVID-19. One of the theories under investigation is that fat cells (adipocytes) act as a reservoir for SARS-CoV-2 and increase viral load in obese or overweight individuals. Scientists also suspect that during infection fat cells release into the bloodstream substances that boost the inflammatory reaction triggered by the virus in the organism. These hypotheses are being investigated by researchers at the [...]