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Microscopy images reveal significant differences in size and structure between brain organoids derived from a patient with Pitt-Hopkins Syndrome (right) and from a control (left). Credit: UC San Diego Health Sciences University of California San Diego (UCSD) study uses lab-grown human brain tissue to identify neural abnormalities in Pitt-Hopkins Syndrome and test gene therapy tools. In a study published on May 02, 2022, in the journal Nature Communications, scientists at the University of [...]

The study could serve as the basis for novel strategies to ensure that future generations are not affected by such diseases. Existing treatments are palliative, aimed at improving quality of life for the patient or delaying progression of the disease. A research article published in the journal Science Advances describes a mechanism that helps explain how certain kinds of genetic disorders known as mitochondrial diseases are transmitted from mother to child. The study it reports [...]

Research conducted at the University of Campinas in Brazil was driven by observations of fluctuations in autoluminescence caused by seed germination in cycles regulated by gravitational tides. The rhythms of activity in all biological organisms, both plants and animals, are closely linked to the gravitational tides created by the orbital mechanics of the Sun-Earth-Moon system. This truth has been somewhat neglected by scientific research but is foregrounded in a study by Cristiano de Mello [...]

A water-borne fungus that has led to the extinction of several species of amphibians that spend all or part of their life cycle in water is also threatening terrestrial amphibians. In Brazil, researchers supported by FAPESP detected unprecedented mortality among a genus of tiny frogs known as pumpkin toadlets that live in the Atlantic Rainforest far from any aquatic environments. The animals were severely infected by chytrid fungus (Batrachochytrium dendrobatidis), which causes [...]

Research conducted in Brazil for more than 20 years in the Paraná River basin shows a drastic fall in the number of aquatic insects in the region, which is considered well-preserved and distant from the negative impacts of agriculture, cattle breeding, and urbanization. The fieldwork was done by researchers affiliated with the State University of Maringá’s Center for Research in Limnology, Ichthyology and Aquaculture (NUPELIA-UEM). The data was systematized byGustavo [...]

In an article published in PNAS, researchers affiliated with Butantan Institute describe the genome of Bothrops jararaca and suggest the origin of genes responsible for toxins in its venom. A group led by researchers at Butantan Institute and funded by São Paulo Research Foundation — FAPESP has completed the first sequencing of a Brazilian snake’s genome. The study is reported in an article published in the journal PNAS. It suggests that the nine genes that encode [...]

New study in JAMA also found kids and teens eat less unprocessed and minimally processed foods. The calories that children and adolescents consumed from ultraprocessed foods jumped from 61% to 67% of total caloric intake from 1999 to 2018, according to a new study from researchers at the Friedman School of Nutrition Science & Policy at Tufts University. Published August 10, 2021, in JAMA, the study analyzed dietary intake from 33,795 children and adolescents nationwide. “Some whole [...]

The study shows that the phenomenon can be produced by means of adiabatic compression, without any exchange of heat with the environment. The process aligns the spins of the material’s particles and magnetizes the system. Magnetizing a material without applying an external magnetic field is proposed by researchers at São Paulo State University (UNESP), Brazil, in an article published in the journal Scientific Reports, where they detail the experimental approach used to [...]

Fully occupied intensive care units (ICUs). Physically and mentally exhausted health workers. Chaotically overcrowded hospitals. These and similar problems posed by the COVID-19 pandemic in Brazil have created ideal conditions for the emergence of Candida auris, a microorganism some are calling a “superfungus” because of the speed with which it has developed drug resistance. The first two cases were confirmed in December 2020 at a hospital in Salvador (state of Bahia, Northeast [...]