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Can a high dose of vitamin D administered on admission to hospital improve the condition of patients with moderate or severe COVID-19? The answer is no, according to a Brazilian study published in the Journal of the American Medical Association (JAMA). The article reports a randomized, double-blind, placebo-controlled clinical trial, the kind of study considered the gold standard to evaluate drug efficacy. It was conducted with FAPESP’s support by researchers at [...]

Diodes are widely used electronic devices that act as one-way switches for current. A well-known example is the LED (light-emitting diode), but there is a special class of diodes designed to make use of the phenomenon known as "quantum tunneling". Called resonant-tunneling diodes (RTDs), they are among the fastest semiconductor devices and are used in countless practical applications, such as high-frequency oscillators in the terahertz band, wave emitters, wave detectors, and logic [...]

Aging entails a loss of muscle mass and strength, which in some cases impairs mobility, hinders walking or performance of day-to-day tasks, and exposes the elderly to the risk of falls and hospitalizations. In clinical practice, handgrip measurement is the most widely used method to identify loss of overall muscular strength in older people. Values below 26 kg for men and 16 kg for women have for some time been considered an indication of risk-associated weakness, but these parameters are [...]

The abundant biological and mineral diversity of the Rio Grande Rise, a seamount in the depths of the Atlantic Ocean about 1,500 km from the coast of Brazil, is probably due to a great extent to little-known microscopic creatures. Researchers affiliated with the University of São Paulo's Oceanographic Institute (IO-USP), collaborating with colleagues at the UK's National Oceanography Center, investigated the microorganisms inhabiting the seamount's ferromanganese crusts and [...]

Adults with periodontitis transmit bacteria that can cause the disease in future to their children, and the bacteria remain in the oral cavity even when the children undergo treatment of various kinds, reinforcing the need for preventive care in the first year of a baby’s life. This is the main conclusion of a study conducted at the University of Campinas (UNICAMP) in the state of São Paulo, Brazil. An article on the study is published in Scientific Reports. Periodontitis is an [...]

A group of researchers led by Brazilians has used an innovative model to map gaps in the Amazon rainforest and identify factors that contribute to tree mortality. Water stress, soil fertility, and anthropic forest degradation have the most influence on gap dynamics in the world's largest and most biodiverse tropical rainforest, according to an article on the study published in Scientific Reports. Forest gaps are most frequent in the areas with the highest levels of soil fertility, possibly [...]

A multidisciplinary research group affiliated with the Department of Physical Education’s Human Movement Laboratory (Movi-Lab) at São Paulo State University (UNESP) in Bauru, Brazil, measured step length synergy while crossing obstacles in patients with Parkinson’s disease and concluded that it was 53% lower than in healthy subjects of the same age and weight. Step length is one of the main variables affected by the disease. Synergy, defined as combined operation, refers in [...]

Researchers at the Human Genome and Stem Cell Research Center (HUG-CELL), hosted by the University of São Paulo's Institute of Biosciences (IB-USP) in Brazil, have developed a technique to reconstruct and produce livers in the laboratory. The proof-of-concept study was conducted with rat livers. In the next stage of their research, the scientists will adapt the technique for the production of human livers in order in future to increase the supply of these organs for [...]

In Brazil, researchers are puzzling over socioeconomic and environmental indicators that do not add up. They are concerned with what they call the São Paulo Macrometropolitan Area, a mega-region comprising five metropolitan areas in the state of São Paulo with a total of 180 municipalities, some of which provide ecosystem services while others receive them. The problem is that the former, which provide the others with water, food and power generation inputs, suffer from steep [...]