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Study can orient use of melatonin in the treatment of breast cancer
Publicado em 08 de dezembro de 2020
A Brazilian study published in the Journal of Pineal Research describes a group of genes potentially regulated by the hormone melatonin in some types of cancer, especially breast cancer. According to the authors, the results can be used to guide future personalized therapies for the disease.
“Certain types of tumor appear to correlate directly with the amount of melatonin produced by cells. It’s essential to understand how the hormone influences molecular signaling at the genetic [...]
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Red propolis could be used to treat schistosomiasis
Publicado em 07 dezembro 2020Well-known for its bactericidal and anti-fungal properties, Brazilian red propolis has now been found to act powerfully against the parasite that causes schistosomiasis, reducing the number of eggs and killing the helminths (worms). In experiments performed at Universidade Guarulhos (UnG) in the state of São Paulo, Brazil, with FAPESP’s support, 400 milligrams per kilogram of body weight was a sufficient dose of red propolis to reduce the parasite load by more than 60% in mice [...]ver notícia -
Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases
Publicado em 07 dezembro 2020Adipose tissue is not just a simple reservoir of energy for periods of food scarcity. It contributes significantly to regulation of the metabolism, releasing various molecules into the bloodstream, including microRNAs that modulate the expression of key genes in different parts of the organism, including the liver, pancreas, and muscles. Research has shown that both aging and obesity can impair the production of these regulatory microRNAs by adipose tissue and favor the development of diseases [...]ver notícia -
Researchers create ingredients to produce food by 3D printing
Publicado em 03 dezembro 2020Food engineers in Brazil and France developed gels based on modified starch for use as “ink” to make foods and novel materials by additive manufacturing It is already possible to produce food with a 3D printer, potentially delivering products that suit consumer preferences regarding taste, texture, cost, convenience, and nutrition. In the near future, it will be possible to produce food with personalized shapes, textures, flavors, and colors considered attractive and healthy for [...]ver notícia -
Tree lifespan decline in forests could neutralize part of rise in net carbon uptake
Publicado em 03 dezembro 2020Accelerating tree growth in recent years has been accompanied by a reduction in tree lifespan, which could eventually neutralize part of the increase in net uptake of carbon dioxide (CO2). This trade-off between tree growth and life expectancy applies to forests worldwide, including in the Amazon and other tropical regions, as well as temperate regions and the Arctic. Models and projections of future forest carbon uptake based on the existing system may therefore overestimate the capacity of [...]ver notícia -
Drug attenuates weight gain in animals fed a high-fat diet
Publicado em 02 dezembro 2020A drug originally developed to treat bacterial infections has proved capable of boosting the metabolism and attenuating the weight gain induced by a fatty diet in tests with mice. The study was conducted at the University of Campinas (UNICAMP) with FAPESP's support, and the findings have just been published in the journal Science Advances. According to Marcelo Mori, a professor at the university's Biology Institute (IB-UNICAMP) and principal investigator for the project, the treatment [...]ver notícia -
Molecule that regulates muscle adaptation to exercise is discovered
Publicado em 01 dezembro 2020The onset of any physical exercise program causes muscle pain that can hinder movements as simple as getting up from a sofa. With time and a little persistence, the muscles become accustomed to the effort, developing more strength and endurance. Researchers affiliated with Harvard University in the United States and the University of São Paulo (USP) in Brazil describe the cellular mediator that makes this adaptation to exercise possible in the journal Cell. The mediator is succinate, a [...]ver notícia -
Study sheds light on immune mechanism that triggers cytokine storm typical of COVID-19
Publicado em 01 dezembro 2020Researchers at the University of São Paulo (USP) in Brazil have demonstrated for the first time that in COVID-19 patients an immune mechanism known as the inflammasome participates in activation of the inflammatory process that can damage several organs and even lead to death. An article reporting the findings of the study, which was supported by FAPESP, has just been published in the Journal of Experimental Medicine. According to the authors, the findings support the use of [...]ver notícia -
Genomic analysis of mako shark reveals genes relating to tumor suppression in humans
Publicado em 01 dezembro 2020Anecdotal reports claim that the incidence of cancer in sharks is very low, but there is not enough data to confirm this estimate categorically. A study published in the journal Genomics, however, presents strong evidence of anti-tumor activity in the genome of the Shortfin mako shark, Isurus oxyrinchus. This large pelagic species, which can be as long as 4 meters, inhabits temperate and tropical seas worldwide. It is classified as endangered by IUCN, owing mainly to non-selective longline [...]ver notícia -
Young Brazilians are increasingly keen on conservation- and biodiversity-related topics
Publicado em 24 novembro 2020Young Brazilians are increasingly interested in biodiversity, conservation of the Amazon and science as they begin high school, but school students in the North region are more interested in learning about these subjects, and about local fauna and flora, than their peers in the Southeast. These are some of the findings of a study reported in an article in Science Advances. Part of a Thematic Project supported by FAPESP (São Paulo Research Foundation), the study analyzed data from five [...]ver notícia