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A study reported in Proceedings of the National Academy of Sciences (PNAS) shows how the presence of a specific protein called IL-22BP affects the composition of the gut microbiota and the body's response to bacterial infection. "We discovered that mice that don't produce this protein are more protected against intestinal infections by bacteria like Clostridioides difficile and Citrobacter rodentium," Marco Aurélio Ramirez Vinolo, a co-author of the article, told. He [...]

Even mild cases of COVID-19 can lead to long-term cognitive problems, including memory loss and attention deficit, according to a study by researchers at the University of São Paulo (USP) in Brazil. The study, published in the journal BMC Psychology, emphasizes the need for comprehensive rehabilitation to address these lasting cognitive impacts. The study involved 302 volunteers and found cognitive impairment in 11.7% of those with mild COVID-19, 39.2% with moderate cases, and [...]

A study reported in Proceedings of the National Academy of Sciences (PNAS) shows how the presence of a specific protein called IL-22BP affects the composition of the gut microbiota and the body's response to bacterial infection. "We discovered that mice that don't produce this protein are more protected against intestinal infections by bacteria like Clostridioides difficile and Citrobacter rodentium," Marco Aurélio Ramirez Vinolo, a co-author of the [...]

New Delhi, July 28 (IANS) A novel treatment strategy involving a combination of two drugs has shown promising results in suppressing tumours by an unconventional method. The new approach, detailed in the journal Cancer Discovery, includes LB-100, currently in clinical trials for lung tumours, and WEE1 inhibitors, which prevent tumour DNA repair. The drug combo works by hyperactivating cancer cells to induce stress, making them more susceptible to targeted attack. The study reveals that [...]

A combination of two drugs was capable of suppressing tumors in a non-conventional manner. Instead of inhibiting tumor cell division, as the most widely used medications do, the strategy consisted of hyperactivating oncogenic signaling by these cells to the point where they became stressed. The other drug then attacked the stressed cells. The approach will be tested in colorectal cancer patients in the Netherlands later this year. The study is reported in an [...]

A combination of two drugs was capable of suppressing tumors in a non-conventional manner. Instead of inhibiting tumor cell division, as the most widely used medications do, the strategy consisted of hyperactivating oncogenic signaling by these cells to the point where they became stressed. The other drug then attacked the stressed cells. The approach will be tested in colorectal cancer patients in the Netherlands later this year. The study is reported in an article published in Cancer [...]

Researchers at the Federal University of São Paulo (UNIFESP) and the University of São Paulo (USP) supported by FAPESP have determined, for the first time with precision, the vertical limits of the marine environments in the Southwest Atlantic, the region comprising the offshore and coastal zones of the Atlantic side of South America. The study is reported in an article published in the journal Marine Environmental Research. The main finding is the upper boundary [...]

Memory loss and attention deficit are frequent complaints of people who have survived severe COVID-19, but these and other cognitive impairments have also been observed in mild patients more than 18 months after the start of the infection, according to a study by researchers at the University of São Paulo (USP) in Brazil. An article on the study is published in the journal BMC Psychology. The findings highlight the need for more comprehensive rehabilitation to address the [...]

A group of researchers supported by FAPESP has found that the key criteria according to which areas of Atlantic Rainforest can be legally cleared by their owners are defined in too "subjective and imprecise" a manner in Brazil's environmental legislation, allowing for the destruction of valuable forest that provides important ecosystem services. The group proposes changes to simplify the licensing process for landowners while at the same time making conservation policy more [...]