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The Sabiá virus causes an acute hemorrhagic and neurological syndrome. Four fatal cases have been recorded in the state of São Paulo since 1990. The virus has been circulating in Brazil for about 142 years. Genomic analyses of two cases recorded in 2019 and 2020 show that the virus has undergone genetic changes over time, which explains why it was not identified by existing tests. These results are part of a study published in the journal PLOS Neglected Tropical Diseases. The study was [...]

The Sabiá virus causes an acute hemorrhagic and neurological syndrome. Four fatal cases have been recorded in the state of São Paulo since 1990. The virus has been circulating in Brazil for about 142 years. Genomic analyses of two cases recorded in 2019 and 2020 show that the virus has undergone genetic changes over time, which explains why it was not identified by existing tests. These results are part of a study published in the journal PLOS Neglected Tropical Diseases. The study was [...]

The protein p53 is often called the guardian of the genome for its central role in preventing cancer. Yet paradoxically, it is also one of the most frequently mutated and dysfunctional proteins in human tumors. A longstanding mystery has been why p53 - unlike its closely related paralogs p63 and p73 - is so prone to misfolding and forming toxic aggregates. A new study published in Communication Chemistry now provides a detailed molecular explanation for this vulnerability. Led by researchers [...]

Witches' broom disease, caused by the fungus Moniliophthora perniciosa, decimated cocoa crops in southern Bahia state, Brazil, in the 1990s. It was even the subject of a local soap opera and continues to plague the chocolate industry in the Amazon region. However, a recent study published in Scientific Reports offers hope that increased cocoa production in the Amazon region will not rely so heavily on fungicides and fertilizers. Supported by FAPESP and conducted at the Frederico [...]

Like fireflies and many deep-sea creatures, certain fungi can naturally emit light through bioluminescence pathways in which specialized enzymes convert chemical energy into visible light. Medical researchers have used fungal light-producing enzymes in the Fungal Bioluminescence Pathway (FBP) to visually track processes like tumor progression and inflammatory responses. New research published in The FEBS Journal provides insights that may help improve and expand such bioluminescence-based [...]

The protein p53 is often called the guardian of the genome for its central role in preventing cancer. Yet paradoxically, it is also one of the most frequently mutated and dysfunctional proteins in human tumors. A longstanding mystery has been why p53 - unlike its closely related paralogs p63 and p73 - is so prone to misfolding and forming toxic aggregates. A new study published in Communication Chemistry now provides a detailed molecular explanation for this vulnerability. Led by [...]

A lot of time and effort goes into planning routes for space missions. Researchers look for the most efficient path between planets and moons because spaceflight is expensive. Even small gains in efficiency can save millions. An international team of researchers say they've found a method of calculating a more efficient route between Earth and the moon using advanced computer modeling. The new method is based on the theory of functional connections, which helps to reduce the compute [...]

Creatine, one of the most popular supplements among gym-goers and athletes, does not appear to have the anti-inflammatory effect that many imagine. This conclusion comes from a systematic review and meta-analysis conducted in Brazil by researchers at São Paulo State University (UNESP), which evaluated clinical trials in humans. The study indicates that, to date, there is no consistent evidence that creatine reduces inflammatory markers in the body. Supported by FAPESP , the study was [...]

Fuel costs slashed: A new trajectory reduces required velocity change by 58.8 m/s, translating into major fuel and cost savings for lunar missions. L1 point advantage: The route uses the Earth-Moon L1 point for fuel efficiency, uninterrupted communication, and potential tourism or mining operations. Computational breakthrough: Researchers simulated 30 million trajectories using a new mathematical framework, far exceeding previous studies’ capabilities. Researchers announce [...]