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In an article published in the journal Nature Communications, researchers at the University of São Paulo (USP) in Brazil show how protozoans of the genus Leishmania that cause leishmaniasis manipulate a protein that plays an essential role in the organism's defense in order to continue to replicate, preventing the body from vanquishing the disease. The findings of the study reported in the article offer hope for the development of novel treatments for the disease. Some 30,000 new [...]

Fundação de Amparo à Pesquisa do Estado de São Paulo In an article published in the journal Nature Communications, researchers at the University of São Paulo (USP) in Brazil show how protozoans of the genus Leishmania that cause leishmaniasis manipulate a protein that plays an essential role in the organism’s defense in order to continue to replicate, preventing the body from vanquishing the disease. The findings of the study reported in the [...]

Illustrations of scientific experiments play a fundamental role in both science education and the dissemination of scientific knowledge to the general public. Confirming the adage that “a picture is worth a thousand words,” these depictions of famous experiments remain in the minds of those who study them and become definitive versions of the scientific process. Archimedes in the bath discovering the law of buoyancy; Newton refracting sunlight with a prism and defining the [...]

Since the start of the COVID-19 pandemic, a class of corticosteroids called glucocorticoids (GCs) have become established as one of the main treatment options, especially for severe cases, thanks to their anti-inflammatory and immunosuppressant action. Brazilian researchers recently discovered new ways in which these drugs influence the organism's inflammatory response during an infection: they raise levels of endocannabinoids (eCBs), molecules produced by the organism itself and that bind [...]

Since the start of the COVID-19 pandemic, a class of corticosteroids called glucocorticoids (GCs) have become established as one of the main treatment options, especially for severe cases, thanks to their anti-inflammatory and immunosuppressant action. Brazilian researchers recently discovered new ways in which these drugs influence the organism’s inflammatory response during an infection: they raise levels of endocannabinoids (eCBs), molecules produced by the organism itself and that [...]

The Sun's rotation produces changes in its magnetic field, which flips completely every 11 years or so, triggering a phase of intense activity. Solar flares - huge eruptions from the surface of the Sun lasting minutes or hours - emit intense bursts of particles and high levels of electromagnetic radiation. The release of energy during solar flares heats the chromosphere, causing almost full ionization of the atomic hydrogen present in the region. The chromosphere is a thin layer of [...]

Flow cytometry, a laser-based technique employed to detect and analyze the chemical and physical characteristics of cells or particles, is already widely used for the assessment of animal sperm integrity and can be repurposed to analyze human sperm, especially to predict potential male fertility more accurately than traditional methods, according to an article published in the journal Reproductive Toxicology. The article is by researchers at São Paulo State University [...]

Resistance to antibiotics is a problem that alarms the medical and scientific community. Bacteria resistant to three different classes of antibiotics, known as multi-drug resistant (MDR) bacteria, are far from rare. Some are even resistant to all currently available treatments and are known as pan-drug resistant (PDR). They are associated with dangerous infections and listed by the World Health Organization (WHO) as priority pathogens for drug development with maximum urgency. An article [...]

Resistance to antibiotics is a problem that alarms the medical and scientific community. Bacteria resistant to three different classes of antibiotics, known as multi-drug resistant (MDR) bacteria, are far from rare. Some are even resistant to all currently available treatments and are known as pan-drug resistant (PDR). They are associated with dangerous infections and listed by the World Health Organization (WHO) as priority pathogens for drug development with maximum urgency. An [...]