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Washington [US], November 5 (ANI): A study conducted by an international team of researchers with FAPESP's support shows that infection by chikungunya virus can produce even more severe manifestations than the typical symptoms of the disease, such as acute fever, headache, rash, and intense joint and muscle pain. The analysis was performed by 38 researchers affiliated with the Federal University of Ceara (UFC), the University of Sao Paulo (USP), and the Ministry of Health in Brazil, and [...]

Researchers at the University of São Paulo (USP) in Brazil have discovered that the muscle regeneration promoted by aerobic exercise is mediated by changes in oxygen consumption by satellite cells, also known as skeletal muscle stem cells. The discovery is expected to be used to help people recover from injury and combat the loss of muscle mass associated with aging.   Previous research showed that weight lifting and other kinds of strength training increase the number of [...]

The probability that an obese person will develop severe COVID-19 is high regardless of age, sex, ethnicity, and the presence of co-morbidities such as diabetes, high blood pressure, and heart or lung disease, according to a study by Brazilian researchers published in Obesity Research & Clinical Practice. The systematic review and meta-analysis of relevant data in the scientific literature focus on nine clinical studies, which in aggregate reported the evolution of 6,577 COVID-19 patients [...]

Arthritis affects almost 2% of the world's population, or some 150 million people, and currently, there is no completely effective treatment for this chronic disease. A new molecule developed in the laboratory has been shown to have potential therapeutic effects. Tested in mice with genetically induced arthritis, it suppressed the inflammatory process, reducing both inflammation and joint tissue wear and tear. Arthritic mice treated with the substance displayed less pain and swelling and [...]

Researchers affiliated with the University of São Paulo’s Ribeirão Preto Medical School (FMRP-USP) in Brazil have demonstrated the potential of a leukaemia drug, arsenic trioxide, to treat medulloblastoma, a type of brain cancer most common in children. When they tested arsenic trioxide on cells taken from one of the most aggressive subgroups of this type of tumour, they obtained promising results in terms of tumour cell death. The drug also made the tumour cells more [...]

Brazilian and U.S. researchers have developed a molecule called FRW that proved capable of binding to blood vessels in the brain but not in other organs when injected into the bloodstream in tests with mice. They used the technique to produce the first ever complete map of the vasculature of the brain, paving the way for the creation of novel diagnostic imaging strategies and therapies for diseases such as Alzheimer's and Parkinson's. The research was supported by São Paulo [...]

Canadian researchers, working in partnership with Brazilian colleagues, have developed 13 bioluminescence sensors for use in testing the effectiveness of new medical drugs in the laboratory. The study, published in the journalScience Signaling, paves the way for new drugs to be tested and characterized. The biosensors are based on the action of G protein-coupled receptors (GPCRs), which are membrane-bound proteins involved in communication between cells. The researchers did not choose to [...]