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Glioblastoma (GBM), one of the most aggressive types of brain cancer, is one of the greatest challenges for medicine, both because it is difficult to treat and because of its high mortality rate. In Brazil, although no exact figures are available, it is estimated that between 10,000 and 12,000 new cases are diagnosed every year. The disease, which accounts for nearly half (49%) of all brain tumours, has an extremely low survival rate, with most patients living only about 12 months after [...]

El azúcar añadido a los alimentos puede ser el «villano» en lo que respecta a la relación entre el cáncer de estómago y una dieta poco saludable, mientras que la sal aumenta el riesgo de tumores en personas con hábitos considerados saludables. Este es el resultado de un estudio realizado en Brasil y publicado en la revista científica BMC Medicine. El estudio consideró que un patrón dietético poco saludable [...]

Sugar added to food may be the “villain” when it comes to the relationship between stomach cancer and an unhealthy diet, while salt increases the risk of tumours in people with habits considered healthy. This is the result of a study carried out in Brazil and published in the scientific journal BMC Medicine. The study considered an unhealthy dietary pattern (UDP) to be one that included high consumption of processed meats, carbonated drinks high in sugar, and fast food. On [...]

Selenoproteins are crucial for several biological functions, including the breakdown of harmful substances, immune system support, and regulating metabolic processes. However, in specific contexts, these proteins can be misused and shield cancer cells from death. One such protein, glutathione peroxidase 4 (GPX4), is vital in supporting cellular protection and cancer cell survival. “This protective property of GPX4 creates a significant challenge for standard cancer therapies, as [...]

A study of patients with metastatic lung cancer by researchers based in Brazil and the United States has found that their performance in simple physical tests such as sitting down, standing and walking can help physicians arrive at a prognosis and approach to treatment. The findings also included identification in the volunteers’ blood plasma of two substances – serine and M22G – with the potential to become biomarkers capable of indicating which patients are most likely to [...]

Un estudio de pacientes con cáncer de pulmón metastásico realizado por investigadores de Brasil y Estados Unidos ha descubierto que su rendimiento en pruebas físicas sencillas como sentarse, levantarse y caminar puede ayudar a los médicos a llegar a un pronóstico y a un enfoque del tratamiento. Un artículo sobre el estudio se publica en la revista European Journal of Clinical Investigation. Los resultados también incluyeron la [...]

Researchers at the Optics and Photonics Research Center (CePOF) in Brazil and collaborators at the University of Toronto and Princess Margaret Cancer Center in Canada have reported for the first time the effective use of a specific type of phototherapy to eradicate ocular melanoma in mice. Based on pulsed laser, the technique involves the application of a large amount of light in a short period of time to activate a drug. CePOF is a Research, Innovation and Dissemination Center (RIDC) [...]

Many new drugs inhibit the processes that cancer cells need to divide rapidly. So as to inhibit the cancer as a whole. But cancer cells have all sorts of workarounds to get around that effect. As a result, the tumor becomes unresponsive to treatment. That’s why researcher Matheus dos Santos Dias is taking a completely different approach. He had to convince some colleagues before he could start working on this quite surprising idea. After all, you’re not going to give cancer cells [...]

A protein that has been widely studied owing to its association with neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) is also linked to medulloblastoma, a type of central nervous system cancer. Medulloblastoma is one of the most common and aggressive brain tumours in children, arising from undifferentiated cells during early neural development. A study led by a group of Brazilian scientists has shown in vitro and in vivo that the gene VAPB is linked to cell [...]