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Researchers at the University of São Paulo (USP) in Brazil have found that severe COVID-19 is associated with an imbalance in an important immune system signaling pathway. The discovery helps explain at the molecular level why some people infected by SARS-CoV-2 develop a potentially fatal systemic inflammation. It also paves the way to the development of more specific therapies. An article on the study, which was funded by FAPESP, is published in Frontiers in Immunology. The [...]

Experiments involving animals and human cells conducted at the University of São Paulo (USP) in Brazil suggest that niclosamide, an anthelmintic widely used against tapeworms, effectively inhibits SARS-CoV-2 replication as well as the exacerbated inflammatory response that leads to death in many patients with severe COVID-19. More research is needed to find out whether the effects, described in an article published in Science Advances, are confirmed in patients with the disease, and [...]

Testing on humans of a novel COVID-19 vaccine developed in Brazil will begin this year. It performed well in animal trials, as reported in an article published in August in Nature Communications. The scientists responsible for the vaccine have just received authorization from the National Health Surveillance Agency (ANVISA) to begin clinical trials. “There are only some minor adjustments left to be made in the study’s protocol before we submit it once again to the approval of the [...]

At the end of the first month of social distancing, in May 2020, most participants in the study (65%) reported feeling time was passing more slowly. The researchers classified this perception as “time expansion” and found it to be associated with feelings of loneliness and a lack of positive experiences in the period. An even larger proportion (75%) reported feeling less “time pressure”, when the clock appears to go faster, allowing less time for day-to-day tasks and [...]

COVID-19 cases, even those that are mild to moderate in severity, can cause an imbalance in the cardiovascular system of young adults without pre-existing diseases, according to researchers at São Paulo State University (UNESP) in Brazil. The investigators found that obesity and a limited physical activity are key factors in post-COVID-19 recovery that change the autonomic nervous system, affecting the regulation of functions such as blood pressure, heart rate, and [...]