But the curves have dropped surprisingly since then, reaching an average of 3.6 deaths per day in the last 14 days.
Currently, it has become a city in a rapid process of deconfinition in Brazil, the second country in death toll, with almost 139,000 since the start of the pandemic.
The "normalization" of the city includes the reopening of schools, shops, nightlife venues and its famous Opera House built in 1884, when Manaus was the rubber capital of the world.
However, many experts warn about the risks of betting on herd immunity as a public health policy.
Herd immunity from natural infection is not a strategy, but rather the signal of the government's failure to control an outbreak and that is being paid for with lives, tweeted Florian Krammer, professor of microbiology at the Icahn School of Medicine at Mount Sinai Hospital, New York.
Other specialists warn that immunity can be short-lived.
Manaus registered 2,462 deaths since the start of the pandemic.
If it were a country, the city would have the second highest death rate in the world, with 1,007 deaths per million inhabitants. The average for Brazil as a whole is 661 deaths per million inhabitants.