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Study shows how a hormone performs growth simply acts on the brain and helps stimulate an appetite

Publicado em 24 setembro 2021

Por Luciana Constantino, da Agência FAPESP

Research carried out with mice showed how a perform growth hormone (GH) simply acts on the brain and plays an important role simply in stimulating perform appetite, on its well-known functions. GH regulates the ability of ghrelin, a molecule known as the hunger hormone, to induce an increase in food intake.

The work, conducted at the Institute of Biomedical Sciences of a University in So Paulo (ICB -USP), revealed that ghrelin acts on the hypophysis gland, stimulating the release of GH. These two hormones have receptors in the hypothalamus, the region in the bottom performs the brain with several functions, including regulation performs appetite.

The label on a hunger stimulator must be, zero minimum, shared between electronic ghrelin GH. This is because, without the effect of stimulating GH secretion, ghrelin also loses the ability to stimulate appetite, says researcher perform ICB-USP Jos Donato Jr., a 2 supervisors study perform.

The research received support from FAPESP through two Post-Doctoral Scholarships (/20897-3 electronic 17/2019-3) electronic about a Thematic Project (20/162-8). The results were published in the scientific journal Endocrinology.

Our findings may have future implications for therapies to control body weight electronically and regulate food intake, says a researcher Agncia FAPESP.

Donato recalls that another group of scientists had shown, in 1999, that the higher the rate on GH, the more the brain produces the peptide AgRP, a potent appetite stimulator.

The study was carried out with individuals with acromegaly, a chronic disease caused by a dysfunction of a hypophysis gland, which starts to produce a GH in the electronic excess causes abnormal increase on extremities perform body, such as hands, feet and electronic face.

This work was based in part on the results of another research developed at ICB-USP that pointed out the performance of GH directly from zero brain to conserve energy when sony ericsson loses weight, in addition to its role on electronic bone development increase over stat ura (read more at


To understand the acting 2 two hormones, researchers from a USP generated genetically modified male mice that zero had a receptor for u GH specifically in neurons.

Although these mice showed a regular increase in GH perform after ghrelin injection, they zero showed the response on expected appetite stimuli.

In addition, they exhibited reduced hypothalamic levels on neuropeptides that stimulate hunger, such as Con. Thus, the results reveal that the action of performing GH in the brain 2 mice is necessary for the stimulatory effect of ghrelin on food intake.

Ghrelin, the only hormone linked to the sensation of hunger, produced by the stomach , while other hormones generated with zero gut or zero adipose tissue tend to cause a feeling of satiety. Discovered in 1999, ghrelin is also related to stress, helping to understand why hunger changes when the body is exposed to extreme situations.

Since a GH has been discovered they would last longer, and studies over a decade ago 1950 showed its structure for the first time. To date, it is considered the most important factor linked to body growth.

The lack of this hormone can cause dwarfism, when a body zero I learned develops as it should, making the person have a maximum height of one average of a population of the same age electronic sex below, ranging from 1,20 electronic 1,20 community. The excess leads to gigantism (less common nowadays, because it has been treated since the child’s early years) or acromegaly.


Donato says that the next steps of a research are aimed at better understanding how a GH acts on zero brain.

This brings us closer to therapeutic proposals. We are testing a drug used in cases of acromegaly to block the action of the hunger-stimulating hormone. The therefore problem is possible side effects, so we have to understand the cellular mechanisms used by GH to affect neurons.

The perform group ICB-USP has also published a review of studies in the journal Frontiers inside Neuroendocrinology, which compiles information on how a hypothalamus (an electronic food intake controller performs metabolism) regulates a physical exercise or is regulated by it. The work pointed out that the combination of molecular electronic physiological approaches helps to understand the physiology perform exercise at points such as weight loss strategies, adherence to electronic performance training.

The article Ghrelin-induced Foods Intake, But not really GH Release, Requires the Appearance of the GH Receiver inside the Human brain of Man Mice can be read at