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Study: Amino acid taurine may be an anti-aging ally (71 notícias)

Publicado em 06 de julho de 2022

By processing the oxygen we breathe and the meals we eat day by day to outlive, our cells create poisonous byproducts generally known as “free radicals.” Some of those molecules carry out obligatory features for the physique, however in extra they will injury the inner buildings of cells, impair their perform and favor the emergence of power illnesses. This course of is named oxidative stress.

Our our bodies have a veritable arsenal of antioxidant enzymes that assist hold reactive oxygen in stability. However, as we age, these regulatory mechanisms change into much less environment friendly. According to a research printed within the journal vitamin Supplementing the weight-reduction plan with the amino acid taurine may be a dietary technique to beat the issue.

In analysis carried out on the University of São Paulo (USP), 24 volunteers between the ages of 55 and 70 have been randomly divided into two teams. Three tablets of 500 mg every (1.5 g per day) have been taken in half every day for 16 weeks. Others took solely tablets containing corn starch (placebo). Neither the members nor the researchers knew which group every belonged to.

Oxidative stress markers have been assessed in blood samples collected earlier than and after the intervention. One of essentially the most fascinating outcomes was an virtually 20% improve within the focus of the enzyme superoxide dismutase (SOD) within the group that obtained taurine – this enzyme decreased by 3.5% within the management group. As the authors clarify, SOD protects the cell from the damaging reactions of the superoxide radical.

By stopping the buildup of free radicals that naturally happen with age, we stop cardiovascular illnesses, diabetes and hypertension, amongst different power circumstances,” evaluates Professor Ellen de Freitas of the Ribeiro Preto School of Physical Education and Sport. EEFERP-USP) and coordinator of a undertaking supported by FAPESP.

According to the researcher, there are only a few research within the scientific literature on the impact of taurine within the context of growing old. “This is a really early research geared toward investigating the optimum dose and doable uncomfortable side effects – which weren’t seen in any of the members.”

Anti-aging remedy

Taurine is a nutrient present in meals corresponding to fish, hen, turkey, purple meat, and seafood. In some tissues of the human physique, particularly the liver, it can be crucial for the perform of the central nervous system, immunity, imaginative and prescient and fertility.

For not less than ten years, the group coordinated by Freitas has been learning the antioxidant and anti-inflammatory results of taurine—initially in excessive-efficiency athletes after which in overweight topics, at doses of three to six grams per day. “The outcomes confirmed that with supplementation of this amino acid, oxidative stress might be managed in these people. Then got here the concept to check the technique within the context of growing old. Because it was nonetheless so new, we began with a really low security dose.” , says Freitas.

The authentic thought was to guage the mixed impact of taurine utilizing bodily train and the 2 interventions individually. Physical exercise is taken into account one of many foremost instruments for regulating the degrees of oxidant and antioxidant substances within the physique, and in the correct quantity, it’s believed to extend the advantages of taurine. However, with the arrival of the pandemic and the truth that the volunteers belong to a gaggle at excessive threat of creating issues from COVID-19, it was determined to maintain solely the dietary a part of the analysis, which might be monitored remotely.

In addition to SOD, two different markers of oxidative stress have been analyzed: the antioxidant enzyme glutathione reductase (GR), which was considerably diminished in each teams, and a biomarker of oxidative stress (MDA), which was elevated by 23% within the management. The ladies who took taurine within the group additionally misplaced an common of 4%.

“This is an alarming impact, however we consider it’s going to be extra important if greater doses of taurine are used”, Freitas assesses.

For Gabriela Abud, at present a doctoral pupil on the Faculty of Medicine of Ribeiro Prieto (FMRP-USP) and first writer of the article, modifications within the volunteers’ weight-reduction plan in the course of the first months of social isolation may have affected the outcomes of the biochemical analyses. .

“In addition to oxidative stress markers, we analyzed concentrations of minerals corresponding to selenium, zinc, magnesium and calcium, that are necessary for the exercise of those enzymes. For instance, selenium is a cofactor of glutathione peroxidase. [que indiretamente ajuda a eliminar o peróxido de hidrogênio do organismo] and decreased in each teams,” says Abud.

As Freitas factors out, taurine supplementation is simply the “icing on the cake” and it alone would not work wonders. “A wholesome way of life, together with a balanced weight-reduction plan and common train, is crucial for the anti-aging impact to happen.”

In the subsequent research, the group plans to incorporate overweight ladies between the ages of 60 and 75 who’ve sarcopenia — a lack of muscle mass related to irritation. “This is a inhabitants at excessive threat of creating issues. We will supply bodily coaching related to day by day supplementation with 3 grams of taurine, in addition to monitor the modifications ensuing from these interventions”, says Freitas.

It ought to be famous that the advantages and dangers of supplementing meals with taurine are nonetheless being investigated. Supplements mustn’t be consumed with out the steerage of a healthcare skilled.

Article Taurine as a Possible Anti-Aging Therapy? A medical managed trial of taurine antioxidant exercise in ladies aged 55 to 70 years. Read right here: www.sciencedirect.com/science/article/abs/pii/S0899900722001198#!.

This textual content was initially printed by Agência FAPESP below the Creative Commons CC-BY-NC-ND license.