A preliminary study by Brazilian researchers warned that The Amazonian form of the coronavirus can circumvent the antibodies produced by the Chinese Coronavac vaccine, Manufactured by the Butantan Institute and the main antidote used in the COVID-19 vaccination campaign in the South American giant.
This was explained by the scientists who conducted the research The data is preliminary Where it was collected from A sample of only eight volunteers, And stated that they will now need confirmation through a broader investigation.
According to what was reported by a Brazilian newspaper Spend, The study was conducted by scientists from the University of São Paulo and the State University of Campinas, known as UNICAMP. It was published on Monday in the “pre-print” section (articles that other scholars have not yet reviewed) of the scientific journal The scalpel.
Scientists collected the plasma from Eight participants Who have obtained Two doses of the Coronavac vaccine About five months ago, I tested the equivalent activity of the antibodies in the plasma against The Brazilian Alternative p 1 s Against the more common pre-neo-brazilian (B) strain.
There they noticed it The level of antibodies capable of stopping the virus was lower for variant P.1 compared to strain B., Being below the detection limit in the test.
But scientists note that this difference It cannot be considered statistically significant Because the volunteer sample was small and the level of neutrality was in both cases. “ very low “.
Likewise, they indicated that, “ The results indicate that P.1 (the Brazilian variant) could evade the neutralizing antibodies induced by the inactivated virus vaccine. Against SARS-CoV-2 (as with Coronavac).
On the other hand, they report that protecting Coronavac from severe cases of COVID-19 (seen in clinical studies) indicates that neutralizing antibodies are not the only protective factor against disease and that other cell responses to our immune system, such as memory T or B lymphocytes, It can reduce the severity of the disease Even if there is such a decrease in the activity of antibodies.
They suggest that to prevent transmission of the new strain, A booster dose may be required Of the inoculum, an up-to-date of this type or other variants shown.
Conclusions of two other studies
The Brazilian Alternative to COVID-19, Adopted in P.1, You can have a viral load of up to ten times and he Able to evade the immune system of those people who already have antibodies Against the Corona virus, two other preliminary studies conducted by Brazilian and English researchers revealed.
“He might do all three at the same time: More transmissible, it invades the immune system and must be more pathogenic He said this Monday in statements to the news agency EFE Ester Sabino, Professor at the University of São Paulo School of Medicine (USP) and coordinator of the USP Group who participated in the research developed by the Brazil and UK Center for the Detection and Diagnosis of Apovirus (CADDE).
This preliminary study, published last Friday, points to that The original new variant of the Amazonas state is 1.4 to 2.2 times more transmissible than the lineages that preceded it Yeah “ Likely It is one of the factors behind the second wave of the Corona virus in Brazil.
Scientists further concluded that the new strain Able to evade the immune system And it causes a new infection in a part of the individuals already infected with the Coronavirus, specifically between 25 and 61%.
“ Many of the cases cannot be explained except for the loss of immunity Most notable is Sabino, who coordinated the study with researcher Nuno Varia from the University of Oxford.
The preliminary study, based on a mathematical model conducted by Imperial College London, is based on analyzing the genomes of 184 nasopharyngeal secretions from patients diagnosed with COVID-19 in a laboratory in Manaus between November 2020 and January 2021.
The capital of the state of Amazonas was the epicenter of the epidemic in Brazil In both the first and second waves of the Coronavirus, it has witnessed a health collapse since the end of last year due to an explosion of cases and income from the Coronavirus.
The research, which has been supported by Fundación de Amparo a las Investigaciones del Estado de São Paulo (FAPESP), has not been reviewed by other scholars or published in scientific journals.
Likewise, another study released last Friday by researchers from the Oswaldo Cruz Foundation in the Amazon region indicated that. The viral load in the organism of individuals with P.1 can be ten times higher.
Brazil, which is one of the countries most affected by the epidemic in the world, has recorded 10587,000 infections since it recorded the first case of the disease, on February 26 of last year, and 255,720 deaths since the first victim was recorded, on February 12. March 2020.
These figures confirm that the Latin American giant, with its population of 210 million, is one of the global hotspots for COVID-19 and the second country in terms of the number of deaths from the disease in the world, surpassed only by the United States, and in third place with more infections after a country. North America and India.