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Gene Therapy Reverses Effects of Autism-Linked Mutation in Human Brain Organoids
Publicado em 04 de maio de 2022
Microscopy images reveal significant differences in size and structure between brain organoids derived from a patient with Pitt-Hopkins syndrome (right) and a control (left). Credit: UC San Diego Health Sciences
A University of California San Diego (UCSD) study is using lab-grown human brain tissue to identify neural abnormalities in Pitt-Hopkins syndrome and test gene therapy tools.
In a study published on May 02, 2022, in the journal Nature Communication, scientists at the [...]
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Gene Therapy Reverses Effects of Autism-Linked Mutation in Brain Organoids
Publicado em 02 maio 2022In a study published in Nature Communicationsscientists at the University of California San Diego School of Medicine used human brain organoids to reveal how a genetic mutation associated with a profound form of autism disrupts neural development. Using gene therapy tools to recover the gene’s function effectively rescued neural structure and function. Several neurological and neuropsychiatric diseases, including autism spectrum disorders (ASD) and schizophrenia have been [...]ver notícia -
Study points to physical principles that underlie quantum Darwinism
Publicado em 27 abril 2022At the atomic and subatomic scales, objects behave in ways that challenge the classical worldview based on day-to-day interactions with macroscopic reality. A familiar example is the discovery that electrons can behave as both particles and waves, depending on the experimental context in which they are observed. To explain this and other phenomena, which appear contrary to the laws of physics inherited from previous centuries, models that are self-consistent but have contradictory [...]ver notícia