Three supercentenarians from Brazil survived COVID-19 in 2020, before vaccines were available, exhibiting strong antibody responses that indicate impressive immune resilience at ages over 110.
Brazil has three of the world’s ten oldest verified men, and its genetically diverse population has over 8 million unique genomic variants, including rare protective genes not typically found in more homogeneous groups.
These supercentenarians possess rare “killer” CD4+ T cells, almost nonexistent in younger individuals, while maintaining cellular cleanup processes similar to those seen in much younger people.
One Brazilian family includes a 109-year-old woman with three nieces aged 100, 104, and 106, further supporting evidence that siblings of centenarians are significantly more likely to live long lives themselves.
If there’s a hint of a fountain of youth, it might just be in Brazil.
In 2020, three supercentenarians in Brazil managed to survive COVID-19 before vaccination options were available. Among them was Sister Inah, who lived until she was 116, making her the oldest verified person in the world. In another instance, a family boasts a 109-year-old matriarch alongside three nieces aged 100, 104, and 106. Researchers studying Brazil’s supercentenarians, those who live to 110 or older, have uncovered valuable patterns about aging and disease resistance.
Brazil stands out with its number of male supercentenarians, featuring three among the ten oldest verified men. The country also surpasses wealthier nations like the United States in terms of female supercentenarians among the longest-lived women globally. Many of these individuals reside in areas with limited access to healthcare, providing a fascinating insight into biological resilience that exists independent of modern medicine.
Much of the research on longevity tends to focus on genetically consistent populations from Europe and East Asia. In contrast, Brazil’s population has evolved through a complex history, including the arrival of Portuguese colonizers in 1500, approximately 4 million enslaved Africans, and later waves of European and Japanese immigrants. A recent study revealed that Brazilian genomes contain over 8 million undescribed variants, including more than 36,000 potentially harmful ones, suggesting that supercentenarians might carry protective genetic variants that remain hidden in other populations.
Brazil’s Supercentenarian Study Design
A study published in Genomic Psychiatry featured contributions from the University of São Paulo’s Human Genome and Stem Cell Research Center. Researchers gathered data from over 100 centenarians, including 20 supercentenarians, from various Brazilian regions with diverse social and cultural backgrounds. They collected clinical data and biological samples for whole-genome sequencing and conducted functional assays.
Three supercentenarians who lived through COVID-19 displayed robust antibody levels against SARS-CoV-2, along with immune-related plasma proteins and metabolites. Some of these individuals engaged in daily activities independently when contacted, showing remarkable clarity in their interactions.
One interesting familial case involved a 109-year-old woman’s nieces, who are 100, 104, and 106. This clustering echoes findings that siblings of centenarians tend to have a significantly higher chance of reaching that age themselves.
Immune Systems Adapted for Longevity
Typically, as people age, their immune systems weaken. But supercentenarians seem to defy this trend.
Their immune cells retain the cleanup capabilities of those found in individuals much younger. Particularly, they’re adept at breaking down damaged proteins, much like taking out the trash before it becomes an overwhelming mess.
What’s intriguing is that supercentenarians possess a special kind of immune cell known as CD4+ T cells that function more like combat cells. Unlike in younger individuals, where CD4+ cells primarily coordinate immune responses, many in those over 110 have transformed into aggressive cells that can eliminate infected or compromised cells.
Moreover, these supercentenarians have an abundance of natural killer cells, the body’s frontline defenders. This unique blend likely aids them in fending off chronic infections that would usually impair most people’s immune responses.
A study of a 112-year-old individual (referred to as M116 in research) uncovered rare genetic variations that influence how the immune system identifies threats and sustains healthy immune cells through aging. Those with these genetic tweaks typically face fewer inflammatory and autoimmune issues as they grow older.
The Genetic Maintenance System
Beyond immune-related genes, the M116 genome revealed rare genetic variations that essentially act as the body’s maintenance crew.
Some genes are instrumental in a process called autophagy, which serves as our cells’ recycling system. It efficiently breaks down damaged proteins and repurposes them, helping avoid the buildup of waste.
Additional unique variants aid mitochondria, the energy factories within our cells. Keeping them functioning efficiently ensures cells remain well-fueled.
Various other variants influence gene regulation and the repair of damaged DNA, forming a comprehensive maintenance system that helps cells operate efficiently for much longer than usual.
Researchers found over 2,000 genetic elements, 5 million DNA letters, and 140 immune variations unique to older Brazilians, none of which appear in global genetic databases. Rather than being anomalies, these are unique adaptations that could clarify why certain Brazilians are living to such advanced ages.
In summary, supercentenarians don’t merely enjoy long lives due to chance. Their bodies significantly resist the normal aging process. Instead of confronting conditions like heart disease, cancer, or dementia at typical ages, they either delay or avoid these afflictions, thanks to a mix of protective genes and environmental factors. Understanding their biological maintenance systems could inform new strategies aimed at promoting healthy aging for more people.
Abraham Katsman