In keeping with the examine, the amino acid taurine might be employed in anti-aging therapies.
Our cells produce doubtlessly poisonous by-products often called “free radicals” after they break down the oxygen we breathe and the meals we eat every day with a purpose to exist. A few of these molecules perform necessary organic capabilities, but when there are too a lot of them, the interior cell buildings could be harmed, impairing the cells’ capacity to operate and probably leading to continual illness. We seek advice from this course of as oxidative stress.
Our our bodies have a exceptional arsenal of antioxidant enzymes that assist in sustaining a wholesome stability of reactive oxygen species, however as we age, these management mechanisms decline. A latest examine revealed within the journal Diet means that supplementing one’s food plan with the amino acid taurine could be a realistic approach to address the issue.
The study reported in the study was carried out at the University of São Paulo (USP) in Brazil. It involved 24 female volunteers aged 55 to 70. They were randomly separated into two groups. One group consumed three 500 mg capsules of taurine per day for 16 weeks (1.5 g per day). The other group received pills that simply contained corn starch (placebo). Neither the volunteers nor the researchers were aware of which group each participant belonged to.
Oxidative stress markers were analyzed in blood samples taken before and after the intervention. One of the most intriguing findings was an almost 20% rise in levels of the antioxidant enzyme superoxide dismutase (SOD) in the taurine group, compared to a 3.5% drop in the control group. SOD, the scientists explain, protects cells from the harmful reactions of the superoxide radical.
“Preventing the buildup of free radicals that naturally occurs with aging probably prevents cardiovascular disease, diabetes, and high blood pressure, among other chronic conditions,” said Ellen de Freitas. Freitas is a professor at the Ribeirão Preto School of Physical Education and Sports (EEFERP-USP) and co-principal investigator for a project supported by FAPESP.
According to Freitas, very few studies of the effects of taurine in the context of aging can be found in the scientific literature. “This study was a first step, aimed at investigating the ideal dose and possible side effects, none of which was observed in any of the participants,” she said.
Anti-aging therapy
Taurine is a nutrient found in certain foods, such as fish, shellfish, chicken, turkey, and beef. Additionally, it is naturally produced in some tissues of the human body, particularly the liver, and is important to the functioning of the central nervous system, immunity, eyesight, and fertility.
The Freitas group has been studying taurine’s antioxidant and anti-inflammatory properties for at least 10 years, initially in high-performance athletes and later in obese people, with daily dosages ranging from 3 g to 6 g. “The results showed that oxidative stress in these individuals could be controlled when their diet was supplemented with this amino acid. We then decided to test the strategy in the context of aging. This was very novel, so we began with a very low safety dose,” Freitas said.
The initial plan was to look at the effects of taurine supplementation in conjunction with exercise training, as well as both treatments separately. Physical activity is thought to be one of the main ways to regulate levels of oxidizing substances and antioxidants in the body, and the proper amount is thought to enhance the benefits of taurine. However, because of the pandemic and the fact that the volunteers were in a high-risk group for COVID-19 complications, the researchers chose to solely proceed with the nutritional component of the study, which could be monitored remotely.
Two other markers of oxidative stress were analyzed besides SOD: the antioxidant enzyme glutathione reductase (GR), which decreased significantly in both groups, and malondialdehyde (MDA), which increased 23% in the control group and decreased 4% in the taurine supplementation group.
“These results were modest, but we believe a higher dose of taurine could produce stronger evidence for its benefits,” Freitas said.
For Gabriela Abud, the first author of the article and currently a Ph.D. candidate at the Ribeirão Preto Medical School (FMRP-USP), changes in the volunteers’ diet in the early months of the pandemic owing to lockdown may have affected the results of the biochemical analysis.
“In addition to markers of oxidative stress, we analyzed levels of minerals such as selenium, zinc, magnesium, and calcium, which are important to the functioning of these enzymes,” Abud explained. “Selenium, for example, is a co-factor for glutathione peroxidase [which indirectly helps eliminate hydrogen peroxide from the organism] and was lowered in each teams.”
For Freitas, taurine supplementation is simply the “cherry on the cake” and can’t work miracles by itself. “A wholesome life-style with a balanced food plan and common train is key for the anti-aging impact to happen,” she stated.
Within the subsequent examine, the group plan to incorporate overweight girls aged 60-75 with sarcopenia, a gradual lack of muscle mass that may be exacerbated by continual irritation. “These folks face an acute threat of creating problems. We’ll supply bodily coaching related to taurine supplementation at 3 g per day and observe the doable alterations as a consequence of these interventions,” Freitas stated.
It is very important keep in mind that the advantages and dangers of dietary taurine supplementation are nonetheless being investigated. Meals dietary supplements shouldn’t be taken with out medical supervision.
Reference: “Taurine as a doable antiaging remedy: A managed medical trial on taurine antioxidant exercise in girls ages 55 to 70” by Gabriela Ferreira Abud M.Sc., Flavia Giolo De Carvalho Ph.D., Gabriela Batitucci Ph.D., Sofia Germano Travieso B.Sc., Carlos Roberto Bueno Junior Ph.D., Fernando Barbosa Junior Ph.D., Julio Sergio Marchini Ph.D. and Ellen Cristinide Freitas Ph.D., 11 June 2022, Diet.
DOI: 10.1016/j.nut.2022.111706