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Study Explains Epigenetic Mechanisms Behind Autoimmune Diseases

Publicado em 04 agosto 2018
São Paulo, Brazil (Scicasts) — A group of researchers at the University of São Paulo (USP) in Brazil used a DNA editing tool called CRISPR/Cas9 to manipulate on of the genes associated to the autoaggressive T lymphocytes responsible for inducing autoimune diseases such as autoimmune polyglandular syndrome type 1 (APS-1) and type 1 diabetes. The autoimmune regulator or "Aire" gene acting in medullary thymic epithelial cells (mTECs) was recently described as playing an important role in [...]