Notícia

Newsbeezer (Brasil)

Researchers are looking for vaccines that can neutralize the coronavirus in the nose

Publicado em 03 setembro 2021

A vaccine in the form of an easy-to-use, inexpensive nasal spray that also provides long-term protection against variants and is able to block the effects of the new coronavirus in the nose, where infections begin.

This is the goal of a project being developed by a research group from the USP (University of São Paulo) in collaboration with Unifesp (Federal University of São Paulo) and Fiocruz (Oswaldo Cruz Foundation).

The new immunization agent, which is still in the early stages of the study, was presented on Monday (08/30) as part of the ILP-FAPESP science and innovation cycle. The event, a partnership between FAPESP and the ILP (Institute of Legislative Paulista) is fully available on YouTube.

“One of the advantages of nasal immunization is that it creates local immunity in the nose, in the oropharynx [parte da garganta logo atrás da boca] and in the lungs. It is exactly the ideal “area” to prevent the consolidation of a SARS-CoV-2 infection. Injectable vaccines are very well suited to induce systemic immunity and also in the lungs, but they are not particularly good at creating a protective reaction in the nasal and oropharyngeal areas, “explains Edécio Cunha Neto, professor at the FM USP (Faculty of Medicine) and research assistant at the Immunology Laboratory of the InCor (Heart Institute).

The project, in which he is one of the main researchers, is supported by FAPESP and by Jorge Elias Kalil Filho, professor at FM-USP and head of the HC-FM-USP-1; Clinical immunology and allergy laboratory in the Hospital das Clínicas.

“The vaccines that exist today are excellent and have been developed in record time, but what we need now is a second generation immunizer that is capable of overcoming the problems encountered during immunization.” [escape imune ou efeitos adversos, por exemplo] and serve as reinforcement for injectables, “said Cunha Neto.

The researcher’s goal is to develop a vaccine that generates long-lasting neutralizing antibodies and also strongly stimulates cellular immunity – mediated by T lymphocytes, which recognize the pathogen and destroy infected cells.

In addition, the new vaccine is said to protect against strains of concern. To do this, the researchers are developing an antigen that can contain the region of the protein S (spike, present on the surface of the virus), which simultaneously binds to human cells (RBD) of three or four variants.

The antigen also contains pieces of protein that stimulate the cellular response for longer than that mediated by neutralizing antibodies. Therefore, it should include the so-called CD8 + cytotoxic T lymphocytes, which kill infected cells, and the CD4 + T lymphocytes, which aid in antibody production and cytotoxic reactions.

The team is currently testing 25 different combinations of proteins encapsulated in ceramic nanoparticles covered with a polymer to ensure the immunization agent adheres to the nasal environment.

Preliminary tests with two doses of prototype antigens produced high levels of neutralizing antibodies in mice. Cunha Neto emphasizes that the expected product should still be stable at room temperature, in addition to its safety, low cost and mastery of the entire manufacturing process in the country.

Clinical studies are expected to be conducted in 2022.

Genome monitoring

In order to know which variants a vaccine should target, it is important to know which strains are most common in the country. For this purpose, some groups in Brazil carry out what is known as genome monitoring. The work is to sequence the genome of the variants in circulation to identify those that are of most epidemiological concern.

In partnership with the city of São Paulo, the FAPESP-supported Joint Brazil-UK Center for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology (CADDE) is monitoring the prevalence of the delta variant of SARS-CoV-2 in the city. .

“Initially the percentage of this variety was 2%, but it has grown systematically and spread to different parts of São Paulo. Today we are at around 33%. Unfortunately, the delta will predominate in the coming weeks, “he said Ester Sabino, professor at FM-USP and researcher at IMT-USP (Institute for Tropical Medicine).

Another speaker was Fernando Spilki, Dean of Research at Universidade Feevale and coordinator of the Corona-Ômica network of MCTI (Ministry of Science, Technology and Innovation) established in 2020 to lead genome surveillance efforts in the country. Among other things, the researcher spoke of efforts to integrate data from across the country.

Sandra Vessoni, director of the Scientific Development Center at the Butantan Institute and coordinator of the SARS-CoV-2 Variant Alert Network in the state of São Paulo, spoke about monitoring, diagnosing and defining the vaccine strategy implemented by the institution.

Paola Cristina Resende Silva, researcher at the Respiratory and Measles Virus Laboratory at the Instituto Oswaldo Cruz / Fiocruz, coordinator of the team of curators of the GISAID data platform in Brazil, explained how the work in the repository that collects data on variant sequencing is carried out from around the world.

The meeting, mediated by Carlos Américo Pacheco, Director-President of the Technical-Administrative Council of FAPESP, was also attended by Karina do Carmo, President of ILP, and Deputy Patricia Bezerra, President of the ALESP Health Commission.

Essa notícia também repercutiu nos veículos:
Folha de S. Paulo IstoÉ Dinheiro online Diário de Pernambuco online IstoÉ online Folha de Pernambuco online Agência Brasil O Globo online Portal R7 IstoÉ Dinheiro online UOL Rede TV! Folha.com Araraquara24horas Visão (Portugal) online Diário Arapiraca N5 Notícias CV Agora Pauta Brasil Garanhuns Notícias Garanhuns Notícias Portal Bueno Aqui Acontece V9 Vitoriosa Online Ururau Portal Jornal Café Impresso Portal Litoral Sul O Correio do Povo (Jaraguá do Sul, SC) online Sinal News Portal da Cidade (Cabo Frio, RJ) SRZD - Sidney Rezende SC Hoje News Grupo Chiru Emissoras de Rádio Super Rádio Tupi FM 96,5 Pelo Mundo DF Ponta Porã Informa I7 Notícias Jornal de Jundiaí online Revista Cenarium online Dia Online (Goiânia, GO) O Bom da Notícia O Liberal (PA) online Sul in Foco Diário de Votuporanga online AnaMaria Jornal Cidade (Marília. SP) AJN1 - Agência Jornal de Notícias Público A RP10 eLimeira Remo News (Índia) SWI swissinfo.ch (Suíça) Olhar Digital Agrosoft La Super Discoteca (EUA) Perú Despierta (Peru) América Noticias (Peru) Tu Pasion Deportiva (Peru) Tv Luz (República Dominicana) MaisAM Portal Rondon Dia Online Patos em Destaque Portal de Notícias Primeiro a Saber Ma10 A Voz do Campo Baixada News News Cariri Portal do Dan Conecta Corinto Jornal Estação online Toda Palavra online Notícias da Sua Cidade A Voz dos Municípios (Laranjeiras, Sergipe) online Sou Catarinense Cabreúva Online Lucas em foco Jundiaí Online Blog 3 Poderes Saúdeinevidência Relata Bahia Manchete Política Jornal Tabloide online (Cotia, SP) TV Caparaó Noroeste Acontece online Rádio Cristalina FM 103.7 Dourados Informa InfoMoney ISMEP - Instituto Santa Marta de Ensino e Pesquisa Época Negócios online Hoje em Dia online Administradores Dinheiro Rural online Portal Engeplus DeFato Online O Povo online Rádio Itatiaia O Paraná (Cascavel, PR) online JMais Jornal do Sudoeste A Crítica (AM) online Bem Paraná online O Progresso (Dourados, MS) online São Carlos Agora SpaceMoney Cruzeiro do Sul online Diário Corumbaense online Portal GMC Online Diário Popular IPTV Click Guarulhos Mais Expressão Murray Advogados Acontece Botucatu Oficial News Minuto Cidade Hora PR Dominican News (República Dominicana) Global News (Chile) Somos Prensa NNN - Nam News Network (Malásia) HT Noticias (República Dominicana) Gaceta Ucayalina (Peru) El Tiempo (México) Latinus (EUA) LabNetwork Informativo Virtual Índices Bovespa Guatemala News Ecuador en Directo (Equador) Agora Região Around World Journal Tribuna União BSB Digital Cotia 24 horas Estúdio Livre News Giro Goiás ID Brasil Blog O Correspondente Passando na Hora DF A Cidade On (São Carlos, SP) Jornal o Brasiliense Notícias Brasil Portal Terra Santa Notícias Rádio Leme FM Dia a Dia Nordeste Blog O Correspondente Guarantã News Jornal A Cidade (Ponta Porã, MS) El Día (República Dominicana) Acceso Peru (Peru) 800 Noticias (Venezuela) Folha da Minha Sampa Notícia em Tempo TV Brusque Liga Democrática São Bento em Foco Tribuna Paulista Portal Gongogi FMUSP - Faculdade de Medicina da USP TelevenTV (Venezuela) Entorno inteligente (Venezuela) Beto Ribeiro Repórter Notícias do Mundo Baía da Lusofonia (Portugal) Noticiero Venevisión (Venezuela) Entorno inteligente (Venezuela) Acontece Botucatu Jornal Americanense Diário da Saúde Info na VWeb Pequi FM 87,5 Imbaú FM 87,9 Aracaju Magazine Notícias SP+ Play Crazy Game Agência Lusa (Portugal) Notícias Botucatu Tribuna Paulista Panorâmica News Notícias em Foco Lombarts Comunicação São Carlos Agora Notícias & Artigos Agora ES online Te Lo Cuento News (EUA) Misto Brasília Região Noroeste 24 Brasil Veja São Paulo online Notícias de Coimbra (Portugal) Blog Crato Notícias Expresso 222 Portal Varada Rede Brasil Atual Revista Pará Rádio Liberdade FM 87,9 Rádio Sat Peruíbe FM 87,9 Roberto Crispim Rádio Nova Onda FM 87,9 Rádio Cidade Nova FM 104,9 Rádio Cultura FM 101,7 Rádio Nova Aliança FM 105,9 Notícias ao Minuto RC 8:32 Gforum MSN (Portugal) MSN (Portugal) Notícias de Coimbra (Portugal) Blog A Crítica Diario El Nacionalista (Venezuela) Noticia y Punto (Venezuela) Suresnoticia (Venezuela) FOCEP Brasil Programa InfoSalud (Argentina) Belém online Veja Saúde online Mais Goiás Nada Pra Fazer Adamantina Net Folha Regional (Flórida Paulista, SP) online Jornal de Itatiba online Aconteceu no Vale FEDAP - Fundação de Estudos para o Desenvolvimento da Administração Pública Portal da Cidade (Registro, SP) SIC Notícias (Portugal) Biblioteca FMUSP Noticias RTV (Espanha) Novo Cantu Notícias Grupo News Paraná Portal Afunilados Toni Rodrigues Acontece no RS Oeste 360 Diário D4 Notícias Extra News MS Pelo Mundo DF Campo Belo em Foco Grava News - Jornal de Alfenas Play Crazy Game ABC (Paraguai) online El País (Uruguai) online Super Rádio Tupi FM 96,5 Oro Noticias (México) Vanguardia Liberal (Colômbia) online El Informador Dominicano (República Dominicana) Quiosco (República Dominicana) El Nuevo Diario (República Dominicana) Alberto News (Venezuela) El Veedor Digital (República Dominicana) El Titular (República Dominicana) Diario Libre (República Dominicana) online Quiosco (República Dominicana) Telenord (República Dominicana) Agencia de Noticias Andina (Peru) Efecto Mundial (México) El Informador (México) online Es! Diario Popular (México) online Diario El Carabobeño (Espanha) Notícias ao Minuto (Portugal) Sapo Lifestyle (Portugal) MSN (Portugal) PubliMetro (Colômbia) El Comercio (Equador) Programa InfoSalud (Argentina) Lado.mx (México) El Democrata (México) Altavoz (Peru) Unión Radio 90.3 (Venezuela) ItapoNews Agora ES online Jornal Floripa Jornal Garopaba São Bento em Foco Oeste Ao Vivo Piauí Noticias Blog Saúde e Dicas Verguia Diário de Cuiabá online Confap - Conselho Nacional das Fundações Estaduais de Amparo à Pesquisa Canabrava 104.9 FM O Tempo online Pampulha online Super Notícia 91,7 FM Blog Do Gesso Play Crazy Game CCN es Noticias (Venezuela) El Portal 24 Benefícios News Roraima na Rede Portal do Governo do Estado de São Paulo Mustach Ata News Giro Notícias Goiás Zatum DF Agora Coluna Supinando Mirante da Bocaina Diário em Foco Mix Vale Relato News Penha News Novo Cantu Notícias Conexão Na Cidade Informativo Astral CVN Notícias Grupo News Paraná Oeste 360 Portal de Notícias Virou Manchete Oeste Ao Vivo TV Interbam Antenados O Repórter Regional online Alvo Notícias Campo Belo em Foco Jornal A Voz do Povo online (Uberlândia, MG) Alagoas Agora online Agência de Notícias – Defesa Hora Campinas RP10 G7 Bahia Portal C1.com Jornal Tradição Regional online Blog do Juares Beto Ribeiro Repórter Jornal Ipanema online Mais Santos online Diário do Pará online Jornal do Commercio (PE) online Portal da Enfermagem NewsLab online Quimiweb Melhor Notícia Minuto Cidade Jardim Informa Folha Livre Sidrolândia News Infosaj - Tv Recôncavo Éter 7 News Jornal Ponta Grossa Sistema Costa Norte de Comunicação Jornal Correio Juquery Diário de S.Paulo online Tua Rádio Paracatu News Sul Notícias Virtus Recursos Humanos Rádio Melodia 97,5 FM Metro Jornal online Rádio Continental FM 96.1 Cidade Azul Notícias Hora PR Cenário MT O Impacto (Santarém, PA) online Rápido no Ar Notícia de Limeira Imprensa News Sul Metrópole FM Rádio 96 FM Bauru Aventuras na Historia Online Tem de Tudo Portal RBN