Resistance training and physical exercise have been found to play a crucial role in alleviating symptoms of Alzheimer's disease, according to researchers.
In an article published in the journal Frontiers in Neuroscience, the beneficial effects of exercise were described as a “complementary treatment” for the disease. The study was conducted by Brazilian researchers from the Federal University of São Paulo and the University of São Paulo, who experimented with transgenic mice with a mutation that leads to the formation of beta-amyloid plaques in the brain. After four weeks of training, the mice showed a decrease in the formation of these plaques, which are associated with Alzheimer's disease and can cause problems with brain function.
The researchers also discovered that the training normalized plasma levels of corticosterone, a hormone similar to cortisol in humans. Increased cortisol levels have previously been linked to faster cognitive decline. Henrique Correia Campos, the first author of the article, stated that this finding confirms that physical activity can reverse the neuropathological alterations that cause clinical symptoms of the disease. The research was funded in part by the São Paulo Research Foundation.
The study suggests that the anti-inflammatory effects of resistance training may be the primary reason for its positive effects on Alzheimer's disease. Beatriz Monteiro Longo, the last author of the article and a professor of neurophysiology at the Federal University of São Paulo, explained that resistance exercise is proving to be an effective strategy to prevent or delay the appearance of Alzheimer's symptoms, especially in sporadic cases not directly caused by a single inherited genetic mutation. She attributed this effectiveness to the anti-inflammatory action of resistance exercise.
Previous research from the University of Sydney has also highlighted the protective effects of resistance training on brain areas vulnerable to Alzheimer's disease. The study found that such training can provide protection for up to one year.
In conclusion, resistance training and physical exercise have been shown to have significant benefits in alleviating symptoms of Alzheimer's disease. These findings highlight the importance of incorporating exercise into the treatment and prevention plans for this debilitating condition.
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