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Researchers at the University of São Paulo (USP) in Brazil, partnering with colleagues in Australia, have identified a novel bacterial protein that can keep human cells healthy even when the cells have a heavy bacterial burden. The discovery could lead to new treatments for a wide array of diseases relating to mitochondrial dysfunction, such as cancer and auto-immune disorders. Mitochondria are organelles that supply most of the chemical energy needed to power cells’ biochemical [...]

Wounds of mice treated with hydrogel containing AnxA12–26 were healed completely after 14 days. Credit: image: researchers’ archive Researchers in São Paulo state, Brazil, have developed a low-cost anti-inflammatory hydrogel that in future could help treat chronic skin lesions such as those often seen in people with diabetes. They report the results of animal tests in an article published in the journal Biomedicine & Pharmacotherapy. According to the International [...]

The red blotches in this image of the nematode C. elegans are a pair of neurons with the UPRER pathway activated in response to the odorant molecule 1-undecene. Credit: Evandro de Souza & Max Thompson Aversion to an offending smell can be an indicator of the organism’s capacity to protect itself from harmful substances and live longer. This at least is what happens in the case of nematodes of the species Caenorhabditis elegans. Although nematodes (roundworms or threadworms) do [...]

Low-level laser therapy and associated photobiomodulation is the most effective of the known treatments for tinnitus, according to a study comparing the main therapies in current use, conducted by Brazilian scientists affiliated with the Optics and Photonics Research Center (CEPOF). The study is reported in an article published in the Journal of Personalized Medicine. Some 750 million people suffer from tinnitus worldwide, according to a European study that analyzed five decades of patient [...]

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO The protein PKMzeta is known to be associated with long-term memory formation. Neurological disorders such Alzheimer’s disease, as well as depression and aging, correlate with reduced levels of this protein in the brain. Researchers affiliated with institutions in Brazil and the United States have now discovered a mechanism that helps explain the link and could pave the way to future medical innovations. [...]

A study by researchers at the State University of Campinas showed that although the two types of training produce similar metabolic stress, muscle activation is different.   Peer-Reviewed Publication FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO Which kind of resistance training promotes more muscle growth: low load with many repetitions or high load with fewer repetitions? According to a study conducted at the State University of Campinas [...]

An article published in the journal Microorganisms shows that melatonin, despite its antioxidant effects and role in regulating sleep cycles, can worsen inflammation of the intestine and impair the action of gut microbiota. This community of bacteria and other microbes is important to health, helping control digestion and benefiting the immune system. An imbalance of unhealthy and healthy microbes in the intestines may contribute to weight gain, high blood sugar, above-normal [...]

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO Researchers at the University of Campinas (UNICAMP) and the Federal University of São Carlos (UFSCar) in Brazil have developed an electrochemical sensor that detects Parkinson’s disease at different stages. The device was fabricated using an ordinary 3D printer and proved capable of early diagnosis, also serving as a model for the identification of other diseases, according to an article published [...]

Pain afflicts at least 1.5 billion people worldwide, and despite the availability of various painkilling drugs, not all forms of pain are treatable. Moreover, pain medications can have side-effects such as dependence and tolerance, especially in the case of morphine and other opioids. In search of novel painkillers, researchers at Butantan Institute’s Special Pain and Signaling Laboratory (LEDS) in São Paulo, Brazil, studied TRPV1, a sensory neuron receptor that captures noxious [...]