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Brazilian researchers have used three-dimensional (3D) printing to develop an artificial skin model with properties that are more similar to those of human skin. The structure, called Human Skin Equivalent with Hypodermis (HSEH), could be used in studies to treat diseases and injuries such as wounds and burns, as well as in the development of medicines and cosmetics, without the need for animal testing. The process of producing the material, which is made from stem cells (capable of [...]

An international team of researchers has discovered a new component of the peripheral nervous system that acts by increasing energy metabolism in the body. The finding paves the way for the development of simpler and cheaper drugs to control obesity and weight gain, regardless of the amount of food ingested. In an article published in the journal Nature, researchers from the University of Oxford in the United Kingdom and the Obesity and Comorbidities Research Center (OCRC) describe where and [...]

A study conducted at the Center for Research on Redox Processes in Biomedicine (Redoxoma) helps understand how high blood sugar (hyperglycemia), one of the manifestations of diabetes, can cause thrombosis. The findings, reported in an article published in the Journal of Thrombosis and Haemostasis, can contribute to the development of strategies to prevent cardiovascular dysfunction in diabetics. “The leading causes of death in Brazil and several other Latin American countries are [...]

Elderly people who have symptoms of depression and moderate or severe joint pain tend to show faster cognitive decline, especially in the area of memory. This was shown by a study published in the journal Aging & Mental Health. The conclusions are based on data from 4,718 participants aged 50 and older who were followed up over 12 years. The authors of the article include researchers from the Federal University of São Carlos (UFSCar) in Brazil and University College London (UCL) [...]

A study conducted at the Federal University of São Paulo (UNIFESP) in Brazil has concluded that the use of monochromatic infrared light in conjunction with conventional physical therapy is a promising alternative for the treatment of peripheral diabetic neuropathy, a type of nerve damage that most often affects the legs and feet, and one of the most frequent, insidious and incapacitating complications of diabetes. “The problem is mainly associated with the duration of diabetes [...]

Using sequencing techniques, researchers associated 51 mutations in mitochondrial DNA with amyotrophic lateral sclerosis (ALS), an incurable degenerative neurological disorder that leads to muscle atrophy and paralysis. Thirteen of the mutations increased the risk of ALS, while 38 were protective. The study suggests these mutations may be important for future tests and research on ALS. The study is published in the journal Muscle & Nerve. It is worth recalling that mitochondria, the [...]

Rapid side-to-side eye movements can help stabilize posture, avoid falls and maintain balance for people with Parkinson’s disease, just as they can for healthy people. This seemingly counterintuitive conclusion was reached by researchers at São Paulo State University (UNESP) in Brazil and the University of Lille in France in a study supported by FAPESP. An article on the study is published in the journal Biomechanics. Ten individuals diagnosed with Parkinson’s and 11 [...]

A study of patients with metastatic lung cancer by researchers based in Brazil and the United States has found that their performance in simple physical tests such as sitting down, standing, and walking can help physicians arrive at a prognosis and approach to treatment. An article on the study is published in the European Journal of Clinical Investigation. The findings also included identification in the volunteers’ blood plasma of two substances—serine and M22G—with [...]

According to an article published in the journal PLOS Pathogens, severe COVID-19 patients can be divided into two distinct groups: those with a high viral load and relatively little inflammation, and those who continue to suffer from inflammatory complications even after the virus has been completely eliminated. The article describes a study conducted in Brazil by researchers at the University of São Paulo (USP) who analyzed lung autopsies from 47 fatal COVID-19 cases alongside their [...]