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Pain afflicts at least 1.5 billion people worldwide, and despite the availability of various painkilling drugs, not all forms of pain are treatable. Moreover, pain medications can have side effects such as dependence and tolerance, especially in the case of morphine and other opioids. In search of novel painkillers, researchers at Butantan Institute’s Special Pain and Signaling Laboratory (LEDS) in São Paulo, Brazil, studied TRPV1, a sensory neuron receptor that captures noxious [...]

Washington: Strokes are a leading cause of morbidity and mortality in the United States and globally. Several environmental and biological factors are known to influence stroke risk and outcome. A new study led by investigators from Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, analyzed the cerebral blood flow (CBF) regulation of individuals who had experienced strokes. The team found that cerebral autoregulation (CA) -- one of the key [...]

Men who had an overprotective father and little autonomy during childhood may run a 12% higher risk of dying before their 80th birthday. In the case of women who had an overprotective father, the risk of dying before the age of 80 can increase by 22%. On the other hand, for women who were well cared for by their mothers during childhood, the risk may decrease by 14%. Interestingly, the research also showed that men who lived with only one parent in childhood had a 179% higher risk of dying [...]

Quality of life relating to physical and mental health can be a key element in the treatment of obese adults. For this reason, interdisciplinary clinical measures including cognitive behavioural therapy (CBT) may produce more significant outcomes for these people, reducing not just weight but also symptoms of depression. This is the main conclusion of a study conducted in Brazil by the Obesity Research Group at the Federal University of São Paulo (UNIFESP) in Santos, São Paulo [...]

Ageing entails a loss of muscle mass and strength, which in some cases impairs mobility, hinders walking or performance of day-to-day tasks, and exposes older people to the risk of falls and hospitalisations. In clinical practice, handgrip measurement is the most widely used method to identify loss of overall muscular strength in older people. Values below 26kg for men and 16kg for women have for some time been considered an indication of risk-associated weakness, but these parameters are [...]

Treatment of depression faces two main challenges. The first is that almost 50% of patients do not respond well to existing antidepressants. The second is that conventional medications take a relatively long time – around three to five weeks – to have the desired effect. A group of researchers affiliated with the University of São Paulo (USP) in Brazil set out to tackle the second problem by using epigenetic modulators to try to ‘erase’ the consequences of stress. [...]