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It is increasingly clear how Nef manages to subvert human cells’ defense mechanisms, enabling HIV to replicate and bringing the symptoms of AIDS closer.
The discovery of a potential “Achilles heel” in Nef, the protein that is crucial to HIV virulence and its capacity to trigger AIDS, paves the way for the development of a new class of drugs against the virus. Researchers have succeeded in demonstrating a structure that binds this protein to another called AP-2 and regulates [...]
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The discovery of a potential "Achilles heel" in Nef, the protein that is crucial to HIV virulence and its capacity to trigger AIDS, paves the way for the development of a new class of drugs against the virus.
Researchers have succeeded in demonstrating a structure that binds this protein to another called AP-2 and regulates endocytosis, the process by which cells take in substances such as nutrients or pathogens by engulfing them in a vesicle.
As a result, it is increasingly clear [...]
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The discovery of a potential “Achilles heel” in Nef, the protein that is crucial to HIV virulence and its capacity to trigger AIDS, paves the way for the development of a new class of drugs against the virus. Researchers have succeeded in demonstrating a structure that binds this protein to another called AP-2 and regulates endocytosis, the process by which cells take in substances such as nutrients or pathogens by engulfing them in a vesicle.
As a result, it is increasingly clear [...]
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The discovery of a possible “Achilles heel” in Nev, the protein essential to HIV and its ability to cause AIDS, paves the way for the development of a new class of drugs against the virus. Researchers have succeeded in showing a structure that binds this protein to another called AP-2 and regulates endocytosis, which is the process by which cells take in substances such as nutrients or pathogens by immersing them in a vesicle.
As a result, it is becoming increasingly clear how Nef [...]
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All these drugs have led to remarkable progress in terms of reducing AIDS morbidity and mortality, but viral resistance and the drugs’ side effects require a non-stop search for new ways of combating the virus.
Some 38 million people were living with the virus worldwide in 2019, including 1.8 million children aged 14 or less, according to the Joint United Nations Program on HIV and AIDS (UNAIDS), which also says 67% had access to antiretroviral therapy. In Brazil, the Health [...]
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The discovery of a potential “Achilles heel” in Nef, the protein that is crucial to HIV virulence and its capacity to trigger AIDS, paves the way for the development of a new class of drugs against the virus. Researchers have succeeded in demonstrating a structure that binds this protein to another called AP-2 and regulates endocytosis, the process by which cells take in substances such as nutrients or pathogens by engulfing them in a vesicle.
As a result, it is increasingly clear [...]
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The discovery of a potential “Achilles heel” in Nef, the protein that is crucial to HIV virulence and its capacity to trigger AIDS, paves the way for the development of a new class of drugs against the virus. Researchers have succeeded in demonstrating a structure that binds this protein to another called AP-2 and regulates endocytosis, the process by which cells take in substances such as nutrients or pathogens by engulfing them in a vesicle.
As a result, it is increasingly clear [...]
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Luciana Constantino | Agência FAPESP – A descoberta de um potencial “calcanhar de aquiles” da proteína Nef, crucial na virulência do HIV e em sua capacidade de desencadear a Aids, abre caminhos para a busca de uma nova classe de medicamentos contra o vírus. Pesquisadores conseguiram demonstrar uma estrutura que liga essa proteína a outra, chamada AP-2, e cuja função é regular a entrada na célula.
Com isso, [...]
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Pesquisadores publicaram achado em revista científica inglesa
Pesquisadores da Faculdade de Medicina da USP de Ribeirão Preto descobriram uma potencial fraqueza da proteína Nef, crucial na virulência do HIV. A descoberta abre caminho para a busca de uma nova classe de medicamentos contra o vírus. O estudo permitiu demonstrar uma estrutura que liga essa proteína a outra, chamada AP-2, e cuja função é regular a entrada na [...]
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AGÊNCIA FAPESP - A descoberta de um potencial "calcanhar de aquiles" da proteína Nef, crucial na virulência do HIV e em sua capacidade de desencadear a Aids, abre caminhos para a busca de uma nova classe de medicamentos contra o vírus. Pesquisadores conseguiram demonstrar uma estrutura que liga essa proteína a outra, chamada AP-2, e cuja função é regular a entrada na célula.
Com isso, está ficando cada vez mais [...]
