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Oxytocin might help stop osteoporosis

Publicado em 10 agosto 2020

Por Maria Fernanda Ziegler | Agência FAPESP

Oxytocin, produced by the hypothalamus and typically often called the “love hormone” for its involvement in pair bonding and orgasm, generally is a robust ally within the management and prevention of osteoporosis, in line with a examine by scientists at São Paulo State University (UNESP) in Brazil.

The examine confirmed that when administered to feminine rats on the finish of their fertile interval, the hormone reversed precursors of osteoporosis, resembling lowered bone density, decreased bone energy and a scarcity of gear that promote bone formation.

“Our research focuses on the prevention of primary osteoporosis, so we investigate physiological processes that occur during the premenopausal period. In this part of a woman’s life, measures can be taken to prevent bone brittleness and fractures, which lead to lower quality of life and can shorten life expectancy,” mentioned Rita Menegati Dornelles, a researcher affiliated with UNESP’s Araçatuba Dental School (FOA). Dornelles heads the Endocrine Physiology and Aging Laboratory within the faculty’s Department of Basic Sciences.

The examine was supported by São Paulo Research Foundation—FAPESP. An outline of the examine is printed in Scientific Reports.

According to Dornelles, the important hormonal milestones in a girl’s life are puberty and perimenopause, a transitional interval beginning some years earlier than menopause itself because the ovaries step by step start to provide much less estrogen. These milestones mark the start and finish of fertility, respectively.

“There’s a lot of research on the postmenopause phase, which follows a woman’s last period, but hormone swings in perimenopause are already sharp and are associated with a gradual decrease in bone density,” Dornelles mentioned. “More research is needed to support the prevention of osteoporosis during perimenopause, as the period after menopause represents about a third of a woman’s life and should have the best quality possible.”

In the examine, the researchers administered two doses of oxytocin 12 hours aside to 10 feminine Wistar rats. They had been 18 months previous, an unusually superior age for laboratory rats, which have a mean life expectancy of three years. Most in vivo experiments contain younger rats which have been ovariectomized, i.e., had their ovaries surgically eliminated. The examine concerned rats in “peri-estropause”, thought-about to be the equal of perimenopause in people, that had been present process a pure ageing course of.

Thirty-five days after oxytocin was administered, the researchers analyzed blood samples and samples of tissue from the femoral neck (the higher portion of the femur slightly below the hip joint and the commonest location for a hip fracture), evaluating the outcomes with these for ten 18-month-old feminine Wistar rats that weren’t given the hormone.

There was no proof of osteopenia (lack of bone density) within the animals handled with oxytocin, in distinction with the management group. “Our results demonstrated that oxytocin helps to modulate the bone remodeling cycle in senescent rats,” Dornelles mentioned. “The animals that received the hormone displayed an increase in biochemical markers associated with bone renewal and in the expression of proteins that support bone formation and mineralization.”

Analysis of the blood samples confirmed elevated exercise of key bone formation markers, resembling alkaline phosphatase. “This substance is produced by osteogenic cells and associated with mineralization. We also observed reduced activity of tartrate-resistant acid phosphatase, a marker of bone resorption,” Dornelles mentioned.

The rats handled with oxytocin had denser bones. “We found the femoral neck region to be stronger and less porous. Its biomechanical compression response was better, and it had physico-chemical properties that guaranteed higher density,” she mentioned.

Secreted in bone

Oxytocin is produced by the hypothalamus and launched by the pituitary gland. Scientists found early within the twentieth century that its launch is related primarily with childbirth and breastfeeding. More latest research have proven that many different cells additionally secrete oxytocin.

“It’s secreted by bone cells, and our research has evidenced its association with bone metabolism in females during the aging process. Osteoporosis is more frequent among postmenopausal women, who generally tend to have lower blood plasma levels of oxytocin,” Dornelles mentioned.

The UNESP analysis group has been learning the involvement of oxytocin in bone metabolism for ten years. “In this time span, we’ve succeeded in characterizing animal models that simulate perimenopause in women,” Dornelles mentioned.

More damaged bones

According to the World Health Organization (WHO), the variety of hip fractures related to osteoporosis is projected to extend 630% in Brazil by 2050, in contrast with 50% in developed nations. “The rise has to do with the aging of the Brazilian population,” Dornelles mentioned, including that high quality of life, eating regimen and bodily exercise are all important disease prevention elements.

In the examine, the researchers centered on the femoral neck as a result of it’s the commonest location for hip fractures, that are 3 times as frequent in ladies as in males. “The consequences of these fractures are very drastic, including loss of mobility and comorbidities,” Dornelles mentioned, including that hip fractures are related to excessive mortality charges: 24% of sufferers die inside 12 months of a hip fracture, and the heightened danger of demise can persist for a minimum of 5 years.

“Loss of function and independence is profound among survivors,” she mentioned. “Approximately 40% become unable to walk independently, and about two-thirds of these need help a year later. Less than half recover their previous level of function.”

In the longer term, researchers plan to check the consequences of oxytocin on osteoporosis prevention in people. “The hormone is naturally produced in our organism and has been synthesized in the lab. Even so, a long study will be needed to assess its safety and effectiveness and to estimate the appropriate dosage,” Dornelles mentioned.