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Researchers have made discoveries about the mechanisms involved in dental pulp inflammation and root apex damage that pave the way for a search for medications that can be used to inhibit the bone loss due to endodontic infection. The key element in the mechanisms is tumor necrosis factor-α receptor-1 (TNFR1), which becomes pro-inflammatory on binding to the cytokine TNF-α. In one of the scenarios analysed, the TNF-α-TNFR1 signaling pathway protected teeth and permitted [...]