细菌与癌症的关系一直都十分微妙，1990年科学家首次发现了幽门螺旋杆菌在胃癌中的致病性，证明了细菌可能具有阻止癌细胞“自杀”的能力。去年5月，一篇关于恶性肿瘤内部细菌的研究登上了世界顶级学术期刊《Science》杂志的封面，更是加深了学术界对细菌可能是癌症的“帮凶”这一说法的怀疑。
DOI：10.1126 / science.aay9189
人体作为一座生理之岛，寄存着数以万亿计的细菌和其他微生物。其中口腔作为数百万细菌的温床，就有大约700多种常驻菌种。可这些口腔中的细菌到底从何而来呢？
科学家发现，随着人们生活水平的提升，各类美食腐蚀着我们的牙齿，因此我们难免要换上假牙。作为口腔中的“异物”，假牙一般多采用高硬度树脂材料，具有多孔性与吸水性等独特的性质，因此相比于真牙，更容易藏污纳垢，成为口腔内细菌的根据地。
不仅如此，这些口腔内的细菌还会默默作怪。近日，圣保罗大学（USP）的科研人员在《Frontiers in Cellular and Infection Microbiology》杂志发表了一篇题为Proto-Oncogenes and Cell Cycle Gene Expression in Normal and Neoplastic Oral Epithelial Cells Stimulated With Soluble Factors From Single and Dual Biofilms of Candida albicans and Staphylococcus aureus的最新研究，对口腔中的细菌与头颈癌的潜在联系进行了一系列的分析。
研究发现，口腔中的真菌和细菌不仅会导致牙周炎、龋齿等疾病，还会激活头颈癌相关基因的表达。
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