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Gene Therapy Reverses Effects of Autism-Linked Mutation in Human Brain Organoids
Publicado em 04 maio 2022
The University of California San Diego (UCSD) study uses lab-grown human brain tissue to identify neural abnormalities in Pitt-Hopkins Syndrome and test gene therapy tools.
In a study published on May 02, 2022, in the journal Nature Communications, scientists at the University of California San Diego School of Medicine used human brain organoids to discover how a genetic mutation associated with a severe form of autism disrupts neural development. Using gene therapy tools to recover the [...]
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Study uses brain organoids to reveal how autism-linked genetic mutation disrupts neural development
Publicado em 03 maio 2022Nature Communications, scientists at the University of California San Diego School of Medicine used human brain organoids to reveal how a genetic mutation associated with a profound form of autism disrupts neural development. Using gene therapy tools to recover the gene’s function effectively rescued neural structure and function. Several neurological and neuropsychiatric diseases, including autism spectrum disorders (ASD) and schizophrenia have been linked to mutations in [...]ver notícia -
Gene Therapy Reverses Effects of Autism-Linked Mutation in Brain Organoids
Publicado em 02 maio 2022Summary: A brain organoid study reveals how a genetic mutation associated with Pitt-Hopkins syndrome, a profound form of autism, disrupts neural development. Using gene-editing technology, researchers recovered the function of the TCF4 gene and effectively restored neural structure and function. Source: UCSD In a study published in Nature Communicationsscientists at the University of California San Diego School of Medicine used human brain organoids to reveal how a genetic [...]ver notícia