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New molecules associated with hyperinflation on covid-19 are identified

Publicado em 20 janeiro 2021

Severe and severe cases of covid-19 also have as characteristic a system of systemic inflammation that, in addition to the pulses, lives on the different organs of the patient. It is an inflammatory reaction for control, which involves raising taxes on circulating pro-inflammatory molecules in blood – fat known as cytocine temperature. This exacerbated immunological response tends to cause major ailments such as virus infection.

University of São Paulo (USP) inspectors at the Ribeirão Preto and the Federal University of São Carlos (UFSCar) demonstrated, first of all, that the pulmonary inflammatory process, at the rate of cytokines and pregnancies that occur associated with excessive arachidonic acid derivatives) and acetylcholine ̵

1; a substance normally produced in the central nervous system that participates in neuronal communication.

The work was supported by FAPESP through a project that invests in biomarkets and new therapeutic therapies for COVID-19. The results were published on the medRxiv platform, in the article was revised in pairs.

“To find a high concentration of these molecular components in patient care with four coves of COVID-19, we can support pulmonary and leukocytic cells [do sistema imunológico] liberam, cytokine aloe vera, acetylcholine, arachidonic acid and its derivatives. It’s a big surprise, because there are no tiny liposuction composites since they are described as pulmonary in COVID-19 “, said Lúcia Helena Faccioli, Professor of the Faculty of Pharmaceutical Sciences of Ribeirão Preto (FCFRP-USP).

The search is based on the objectives of the ImunoCovid consortium – a multidisciplinary coalition involving USP and UFSCar inspectors, as well as professionals from the Santa Casa de Misericordia and the São Paulo Hospital in Ribeirão Preto, who work with .

In agreement with the Pesquisadora, the purchase is open for new studies on the participation of non-inflammatory lipid mediators, as can pregnancy and treatment markets of COVID-19.

In addition to two molecular components, USP pseudonyms identify or decrement the expression of CD14 and CD36, glycoproteins from the membrane of fecal cells (leukocytes). I would also like to point out that the use of corticosteroids in reducing inflammation appears in acetylcholine taxes, does not interfere with arachidonic acid and its derivatives.

“In this way, it is beneficial to benefit many patients, the use of corticosteroids to treat hyperinflation does not induce the same results for all to do. For that matter, based on what we have studied, we suggest that we treat it with corticoids are initiated or quantified in hospitalized individuals and by serious and critical quadrants, in combination with individuals of arachidonic acid metabolism “, diz Faccioli.

It is worth noting that inadequate use of corticosteroids can carry risks relevant to the organism. It is important to seek medical advice no matter what the dose, during the period of initiation and duration of treatment. Use this type of medicine that prescribes medicine in the viral phase of the drug, which is antiseptic, can aggravate the infection.

The discovery of important pieces of cabbage-cabbage that involves different molecules in cascading until the cytocine temperature increases. The study was conducted by another group of USPs, including Ribeirão Preto, and demonstrated their participation in an immunological mechanism known as the inflammatory process (leia mais em: agencia.fapesp.br/34680/).

To determine if infection with the SARS-CoV-2 virus affects the metabolism of lipid mediators, the Faccioli group performs analyzes by means of a technique known as high-resolution mass spectrometry. Researchers study the lipidoma (conjunct of molecules of origin lipid) in the blood sanguine of patients with COVID-19 and Saudi volunteers. Sum sum, 8,791 metabolites of this type present in less than 50% of all samples.

On the other hand, the scientists assisted in the production of mediators in the care of 190 patients with COVID-19 (from 16 to 97 years), sent 43 assistants, 44 moderators, 54 engravers and 49 critics. In this form, it is possible to stratify the doctrines in four phases or gray areas of infection: living, moderate, severe and critical. We analyzed the data of 39 Saudi participants and 13 hospitalized sem COVID-19 (non-infected), who form the control group.

The results of this study were confirmed with the analysis of genetic data of pulmonary biopsies of infected patients under SARS-CoV-2 deposited in public repositories and published in scientific articles. But more studies are needed, and the results are new perspectives on COVID-19 treatment.

The article Cholinergic and lipid mediating cross-talk in Covid-19 and the effect of glucocorticoid therapy pode ser lido em www.medrxiv.org/content/10.1101/2021.01.07.20248970v1.

This text was originally published by FAPESP Agency in accordance with the Creative Commons license CC-BY-NC-ND. Rent the original here.