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New molecule shows potential therapeutic effects against arthritis

Publicado em 12 agosto 2020

Por José Tadeu Arantes, da Agência FAPESP

Tested in mice with genetically induced arthritis, it suppressed the inflammatory process, reducing both inflammation and joint tissue wear and tear. Arthritic mice treated with the substance displayed less pain and swelling and had lower clinical scores measuring the extent of the inflammation than untreated arthritic rats.

The findings are reported in an article in The FASEB Journal, published by the Federation of American Societies for Experimental Biology (FASEB).

"The study showed that this new molecule is capable of controlling the most severe manifestations of the disease," Marcelo Henrique Napimoga, principal investigator for the project in Brazil, told Agência FAPESP. Napimoga is Head of Graduate Studies, Research and Extension at São Leopoldo Mandic College (SLMANDIC). The study was part of a Thematic Project supported by FAPESP.

The new molecule is called TPPU, short for 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea. Its function of interest is inhibition of soluble epoxide hydrolase (sEH), an enzyme that plays a key role in activating inflammatory processes and can lead to chronic inflammation.

Our organism naturally produces an anti-inflammatory substance called epoxyeicosatrienoic acid (EET), but sEH converts EET into 1,2-dihydroxyeicosatrienoic acid (DHET), which not only can't control inflammation but also can have proinflammatory effects. Inhibition of sEH is therefore crucial to the treatment of inflammatory diseases such as rheumatoid arthritis. This is what TPPU does," Marcelo Henrique Napimoga, Principal…