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Treatments led to lower severity scores, meta-analysis suggests

Institute of Diabetes and Digestive and Kidney Diseases in Bethesda, Maryland, on the lack of adequate data opens in a new tab or window to support obeticholic acid (Ocaliva) for primary biliary cholangitis. "In the ocean, they get into the food chain, and they get into us." -- Luís Fernando Amato-Lourenco, PhD, of Freie Universität Berlin, talking about microplastics and a new study opens in a new tab or window that detected them in the olfactory bulbs of human [...]

— Findings suggest a pathway for plastic fragments to enter the brain Key Takeaways Microplastics were found in the olfactory bulbs of eight of 15 human brains at autopsy, a case series showed. A total of 16 synthetic polymer particles and fibers were identified, reported Luís Fernando Amato-Lourenco, PhD, of Freie Universität Berlin in Germany, and co-authors. Most microplastics (75%) were particles and 25% were fibers, the researchers wrote in JAMA Network Open [...]

— Role of Brazilian Zika outbreak on baseline dengue immunity needs study, expert says One dose of the live, attenuated, tetravalent dengue vaccine Butantan-DV prevented symptomatic disease through 2-year follow-up, regardless of baseline serostatus, a phase III, placebo-controlled study in Brazil found. Overall, the vaccine was nearly 80% effective in preventing symptomatic dengue during the follow-up period. Among participants with no previous dengue exposure, the vaccine had an [...]

Gray matter atrophy and severe disruption of brain functional connectivity were seen in long COVID patients with anxiety and depression about 3 months after acute mild SARS-CoV-2 infection. Compared with people who were asymptomatic after SARS-CoV-2 infection, long COVID patients with both anxiety and depression showed limbic atrophy and a widespread pattern of hyperconnectivity, reported Clarissa Yasuda, MD, PhD, of the University of Campinas in São Paulo, Brazil, and colleagues, in [...]