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The onset of any physical exercise program causes muscle pain that can hinder movements as simple as getting up from a sofa. With time and a little persistence, the muscles become accustomed to the effort, developing more strength and endurance. Researchers affiliated with Harvard University in the United States and the University of São Paulo (USP) in Brazil describe the cellular mediator that makes this adaptation to exercise possible in the journal Cell. The mediator is succinate, a [...]

Brazilian red propolis found in beehives along the coast and mangroves in the Northeast region contains two substances with anti-cancer properties. In laboratory tests, they considerably reduced the proliferation of ovarian, breast, and brain cancer cells. In a study published in the Journal of Natural Products, researchers at the Universities of São Paulo (USP) and Campinas (UNICAMP) report their discovery of the two anti-cancer substances as well as six novel polyphenols with [...]

Exposure to bisphenol A (BPA), an industrial chemical used to make certain plastics and resins, inner coatings for food cans and bottle tops, thermal paper used in store receipts, dental sealantsm and so on, is a concern because of possible adverse health effects, including a reduction in fertility. A study performed at Harvard Medical School (HMS) in the United States by Maria Fernanda Hornos Carneiro and her research group shows that the harmful effects of BPA can be reversed by [...]

Crotoxin, extracted from the venom of the South American rattlesnake Crotalus durissus terrificus, has been studied for nearly a century for its analgesic, anti-inflammatory and antitumor actions Credit score: Giuseppe Puorto/Butantan Institute Crotoxin, extracted from the venom of the South American rattlesnake Crotalus durissus terrificus, has been studied for nearly a century for its analgesic, anti-inflammatory and antitumor actions and as an much more highly effective muscle paralyzer [...]

A Brazilian study published in the journal Drug and Alcohol Dependence shows that cannabis smoked recreationally does not work as a harm reduction strategy for crack and cocaine addicts undergoing rehabilitation. Instead of reducing their craving for cocaine, whether nasally insufflated in powder form or smoked in the form of crack crystals, cannabis use made the patients' clinical condition worse. The patients were evaluated for six months after discharge from a voluntary inpatient [...]

Using human blood cells, Brazilian researchers have succeeded in obtaining hepatic organoids ("mini-livers") that perform all of the liver's typical functions, such as producing vital proteins, storing vitamins, and secreting bile, among many others. The innovation permits the production of hepatic tissue in the laboratory in only 90 days and may in the future become an alternative to organ transplantation. The study was conducted at the Human Genome and Stem Cell Research Center [...]

Original story by Maria Fernanda Ziegler, Agência FAPESP Using human blood cells, Brazilian researchers have succeeded in obtaining hepatic organoids (“mini-livers”) that perform all of the liver’s typical functions, such as producing vital proteins, storing vitamins, and secreting bile, among many others. The innovation permits the production of hepatic tissue in the laboratory in only 90 days and may in the future become an alternative to organ transplantation. The [...]

A FAPESP-funded study with results published in The Lancet Infectious Diseases has identified markers capable of predicting mortality in patients with symptoms of yellow fever, potentially helping to prevent the development of severe conditions Approximately ten out of every 100 people who are bitten by mosquitoes infected by the yellow fever virus develop symptoms of the disease. Although most infected people do not develop the disease, it is lethal to approximately 40 percent of [...]

Approximately ten out of every 100 people who are bitten by mosquitos infected by the yellow fever virus develop symptoms of the disease. Although most infected people do not develop the disease, it is lethal to approximately 40% of those who do. Outbreaks of yellow fever have occurred in Brazil in recent years despite the existence of a safe and efficacious vaccine since 1938. Even after more than a century of research, scientists and physicians were unaware of any specific clinical and [...]