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Melanopsin (OPN4) is a light-sensing protein found in skin and retina cells. A new study conducted at the University of São Paulo (USP) in Brazil suggests that OPN4 can also participate in the development and progression of melanoma, the most aggressive type of skin cancer. In experiments with animals and genetically modified cells at the Comparative Physiology of Pigmentation Laboratory belonging to the Institute of Biosciences (IB-USP), the researchers showed that the disease [...]

Parkinsons and other neurodegenerative diseases are known to be associated with abnormal accumulation and aggregation of this protein, Fonseca said. FAPESP is aware that the very best research can only be done by working with the best researchers internationally. You may also subscribe to FAPESP news agency at http://agencia. FAPESP. br/subscribe . Research used to focus on the brain, and little progress was made in this direction for decades. People predisposed to sporadic Parkinsons usually [...]

The neurons and interneurons in the human brain communicate via electrical and chemical signals to activate or inhibit nearby neurons as well as circuits in distant brain regions. The role of interneurons In the same issue of the Journal of Neuroscience, the group published another article on synchronous activity of cortical inhibitory interneurons expressing parvalbumin. “The results show that manipulating BDNF/trkB in adults can alter not only brain activity but also complex behaviors [...]