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How a single gene alteration may have separated modern humans from predecessors: Novel study used brain organoids genetically modified to mimic now-extinct Neanderthals

Publicado em 18 fevereiro 2021

As a professor of pediatrics and cellular and molecular medicine at University of California San Diego School of Medicine, Alysson R. "We're looking forward to this new combination of stem cell biology, neuroscience and paleogenomics. The ability to apply the comparative approach of modern humans to other extinct hominins, such as Neanderthals and Denisovans, using brain organoids carrying ancestral genetic variants is an entirely new field of study.". To continue this work, Muotri has teamed up with Katerina Semendeferi, professor of anthropology at UC San Diego and study co-author, to co-direct the new UC San Diego Archealization Center, or ArchC. "We will merge and integrate this amazing stem cell work with anatomic comparisons from several species and neurological conditions to create downstream hypotheses about brain function of our extinct relatives," Semendeferi said. "This neuro-archealization approach will complement efforts to understand the mind of our ancestors and close relatives, like the Neanderthals.".