Do you know: Taking off your superbugs with a pinch of thurmeric In 2017, a tragic incident emerged in Nevada Hospital.
A woman, who took in for pneumonia, succeeded tragically surrendered for multi -organs and sepsis. The culprit? Strain of bacteria developed resistance to 26 different antibiotics. These superbugs, or the antibiotic resistant bacteria, represent one of the most urgent public health threats in the world.
In line with the effort to combat these fatal pathogens, researchers at Texas A & M have now shown that curcumin, the compound that gives a bright yellow color to use its name to reduce antibiotic resistance.
The researchers showed that when curcumin is intentionally given to bacteria as food and are activated with light, it can stimulate harmful reactions within these microbes, and eventually kill them. This process, which they showed, reduces the number of antibiotic resistant songs and again provides traditional antibiotics.
The results of the study are published in the magazine Science reports
Before antibiotics, infectious diseases were the cause of death and disabilities around the world. With the advent of these rescue medications, the lifetime of the person has increased by 23 years. In recent years, although novel antibiotics have access to high level, antibiotic resistant bacteria have become more popular at the same time, using the duration of their superbugs, such as methicillin-resistant are resistant Methicillin face Staphylococcus aureus (MRSA), Enterococcus is resistant to vancomycin, and pneumonia, which is extremely difficult to treat. Indeed, infectious diseases are considered the leading human mortality again, demanding up to 10 million lives each year.
“When bacteria begin to become resistant to traditional antibiotics, we have an antibiotic disaster,” said Dr. Vanderlei Bagato, professor in the Biomedical Engineering Department and the senior author of the study. “To overcome this challenge, we need other ways to kill the superbugs or to find a new way to modify natural processes within the bacteria so that antibiotics begin to act again.”
Bacteria show natural variety within a particular population. This diversity introduces variations in cell behaviors, including a response to antibiotics, which can directly contribute to treatment resistance if some antimicrobial medication songs last and continue to replicate. Therefore, the researchers wanted to prevent bacterial diversity to control bacterial resistance.
Photodynamic deactivation, a technique showing a promise for combat bacterial resistance, light and sensitive light molecules, called photosensitizers, uses to produce reactive oxygen species that can kill micro -organisms by interfering with their metabolic processes. In their experiments, the team also used curcumin, which is a natural food for bacteria. They tested this technique of a song of Staphylococcus aureus are amoxicillin, erythromycin, and gentamicin.
The researchers revealed the bacteria many cycles of light exposure and then compared the minimum antibiotic concentration required to kill the bacteria after light exposure compared to those who did not receive light exposure.
“When we have a mixed population of bacteria where some of them are resistant, we can use photosystem deactivation to narrow the bacterial distribution, leaving behind the more or less strains in their response to antibiotics,” said Bagnato. “It is now much easier to predict the precise antibiotic dose to remove the infection.”
The team noted that photosystem deactivation has a huge potential using curcumin as an adjuvant or additional therapy with antibiotics for diseases, such as pneumonia, due to antibiotic resistant bacteria.
“Photionic deactivation provides a cost-effective treatment option, which is crucial to reducing medical costs not only in developing countries but also in the United States,” said Dr. Vladislav Yakovlev, professor in the Biomedical Engineering Department and author of the study. “There are also potential applications in military medicine, where this technology could be used to treat battle wounds and to prevent the development and spread of antimicrobial resistance, significant concerns in combat cases.”
Participants in the research include Dr. Jennifer Soares, which is the main author of the paper, and Dr. Kate Blanco from São Carlos Institute of Physics, University of São Paulo, Brazil.
This research received financial support from the the São Paulo Research Founda, the National Council for Science and Technology Development, Cancer Prevention and Research Texas Research Institute, the Governor University Research Initiative, the Air Force Science Research Office, and the National Health Institutions.
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