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High Dose of Vitamin D Fails to Improve Condition of Moderate to Severe COVID-19 Patients

Publicado em 06 maio 2021

A medical trial was carried out with 240 clients who were offered 200,000 IU of vitamin D3 on admission to healthcare facility. The supplements did not decrease length of stay or impact the percentage needing extensive care.

Can a high dosage of vitamin D administered on admission to the healthcare facility enhance the condition of clients with moderate or extreme COVID-19? The response is no, according to a Brazilian research study released in the Journal of the American Medical Association (JAMA).

The short article reports a randomized, double-blind, placebo-controlled medical trial, the type of research study thought about the gold requirement to assess drug effectiveness. It was carried out with FAPESP’s assistance by scientists at the University of São Paulo’s Medical School (FM-USP), who hired 240 clients dealt with at Hospital das Clínicas (HC), the healthcare facility complex run by FM-USP, and the Ibirapuera field healthcare facility in São Paulo City in June-August 2020.

“In vitro studies or trials with animals had previously shown that in certain situations vitamin D and its metabolites can have anti-inflammatory and anti-microbial effects, as well as modulating the immune response. We decided to investigate whether a high dose of the substance could have a protective effect in the context of an acute viral infection, reducing either the inflammation or the viral load,” Rosa Pereira, primary private investigator for the job, informed Agência FAPESP.

The supplements of vitamin D3 did not decrease length of stay or impact the percentage needing extensive care. Credit: Rosa Pereira

The volunteers were arbitrarily divided into 2 groups, among which was offered vitamin D3 in a single dosage of 200,000 systems (IU) liquified in a peanut oil option. The other group was offered just the peanut oil option. All individuals were dealt with according to the basic procedure for healthcare facility treatment of the illness, that includes administration of prescription antibiotics and anti-inflammatory drugs.

The primary function was to see if intense supplements would impact the length of healthcare facility stay for these clients, however the scientists likewise wished to learn whether it would reduce the threats of admission to the extensive care system (ICU), intubation and death.

No substantial distinction in between the groups was observed for any of these medical results. According to Pereira, the research study was developed above all to examine the effect on healthcare facility stay and a bigger variety of volunteers would be required to accomplish a clinically appropriate quote of the result on death.

“So far we can say there’s no indication to administer vitamin D to patients who come to the hospital with severe COVID-19,” she stated.

For Bruno Gualano, a scientist at FM-USP and penultimate author of the short article, the findings reveal that a minimum of in the meantime there is no “silver bullet” for the treatment of COVID-19. “But that doesn’t mean continuous use of vitamin D can’t have beneficial effects of some kind,” he stated.

Ideal dosage

Pereira is presently leading a research study at FM-USP to learn whether topics with enough flowing levels of vitamin D fight infection by SARS-CoV-2 much better than those with inadequate levels of the nutrient.

The perfect level of vitamin D in the blood and the day-to-day supplements dosage differ according to age and total health, she discussed. Older individuals and clients with persistent illness consisting of osteoporosis ought to have more than 30 nanograms per milliliter of blood (ng/mL). For healthy grownups, 20 ng/mL is an appropriate limit.

“The ideal approach is case-by-case analysis, if necessary dosing the substance periodically by means of blood work, with supplementation if a deficiency is detected,” Pereira stated.

Reference: “Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19A Randomized Clinical Trial” by Igor H. Murai, PhD; Alan L. Fernandes, PhD; Lucas P. Sales, MSc; Ana J. Pinto, BSc; Karla F. Goessler, PhD; Camila S. C. Duran, MD; Carla B. R. Silva, MD; André S. Franco, MD; Marina B. Macedo, MD, MSc; Henrique H. H. Dalmolin, MD; Janaina Baggio, MD; Guilherme G. M. Balbi, MD; Bruna Z. Reis, PhD; Leila Antonangelo, MD, PhD; Valeria F. Caparbo, PhD; Bruno Gualano, PhD and Rosa M. R. Pereira, MD, PhD, 17 February 2021, JAMA.

DOI: 10.1001/jama.2020.26848

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