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Here's why obese girls, not boys, are at a higher risk of cardiovascular disease

Publicado em 13 maio 2021

A new study has recovered that girls are much apt than boys to make metabolic alterations associated with obesity, specified arsenic precocious humor unit and excessive humor levels of cholesterin and triglycerides (dyslipidemia).

The survey was conducted successful Brazil connected 92 adolescents. The findings of the survey were published successful the diary Frontiers successful Nutrition.

The survey was conducted with FAPESP's enactment by scientists affiliated with the University of Sao Paulo's Biomedical Sciences Institute (ICB-USP) and the Medical School of Santa Casa de Misericordia de Sao Paulo (FCM-SCMSP).

According to the authors, the obese girls displayed a signifier of lipid illustration alterations not seen successful girls without obesity and a higher propensity to make cardiovascular illness successful adulthood.

"We recovered that girls person a overmuch greater inclination to acquisition the alterations emblematic of obesity, specified arsenic elevated humor unit and dyslipidemia. In our study, they had augmented levels of triglycerides and LDL, alleged 'bad cholesterol', portion HDL, 'good cholesterol', was little than successful eutrophic [normal weight] girls," said Estefania Simoes, archetypal writer of the article.

The lipid illustration of the obese boys included successful the survey displayed nary important differences from that of normal-weight boys, according to the researchers.

Childhood obesity is simply a increasing interest among wellness authorities and scientists successful the field. The World Health Organization (WHO) estimates that immoderate 340 cardinal children aged 5-19 worldwide were overweight oregon obese successful 2016. It is good known that puerility obesity is associated with a higher likelihood of metabolic disorders and cardiovascular illness successful adulthood.

A important magnitude of probe shows this, but the differences betwixt boys and girls successful presumption of the effects of obesity person not been studied successful depth.

"We compared obese and non-obese girls and boys aged 11-18, simultaneously addressing anthropometrics, lipid and lipoprotein profile, and hormone and neuropeptide levels, with a peculiar accent connected sex-dependent responses. To our knowledge, this is the archetypal survey to instrumentality this multifactor approach," Simoes said.

The survey was conducted successful collaboration with Ricardo Riyoiti Uchida, a neurologist and psychiatrist who acted arsenic main researcher and recruited the 92 participants astatine the Child Obesity Outpatient Clinic of the Santa Casa de Misericordia Hospital successful Sao Paulo.

Uchida utilized neuroimaging to effort to find retired whether determination are alterations successful the encephalon regions associated with satiety and appetite successful obese subjects.

"An nonfiction connected this taxable is astir to beryllium published, focusing connected characterization of the cardinal tense strategy successful obese patients. Uchida has been studying teen obesity for galore years," Simoes said.

The SCMSP squad took the subjects' humor unit and collected humor samples to measurement fasting serum attraction of full cholesterin (TC), high-density lipoprotein cholesterin (HDL), low-density lipoprotein cholesterin (LDL), very-low-density lipoprotein cholesterin (VLDL), and triglycerides (TG).

The researchers besides looked for binge eating patterns and addiction to high-sugar and high-fat foods utilizing special-purpose questionnaires. They besides measured neuropeptides linked to neuro-humoral alterations and detected important alterations successful obese subjects. Neuropeptides are released successful effect to peripheral signals specified arsenic hormones to modulate appetite and vigor balance.

"In addition, leptin and insulin interact with neuropeptides NPY, MCH and a-MSH, not lone regulating appetite but besides activating the sympathetic tense system, which whitethorn lend to the precocious humor unit associated with obesity," Simoes said.

The caller information connected differences betwixt girls' and boys' hormone, cytokine and neuropeptide profiles points to the request for personalized treatment.

"However overmuch we whitethorn privation to plan a azygous therapeutic strategy based connected drugs oregon nutrient supplements, our findings amusement that girls and boys shouldn't beryllium treated alike adjacent if they person the aforesaid value and age, due to the fact that their organisms respond to attraction differently," Simoes said.

According to Joanna Correia-Lima, 2nd writer of the article, 2 different papers were written utilizing the information collected from the aforesaid radical of volunteers. The first, published successful the International Journal of Obesity, focuses connected characterizing the inflammatory process since systemic chronic inflammation is important successful obese subjects.

"At the laboratory headed by Professor Marilia Seelaender, a co-author with america of some articles, we've agelong been studying a upset that's the other of obesity: cachexia [extreme value nonaccomplishment and musculus wasting, often successful crab and AIDS patients]. Systemic inflammation plays a cardinal relation successful both," Correia-Lima said.

Correia-Lima added, "We archetypal focused connected inflammation and past connected the relation of hormones and however they subordinate to the predisposition to make cardiovascular disease."

Most technological publications connected puerility obesity, she added, absorption connected a azygous circumstantial alteration, specified arsenic inflammation oregon a hormone, for example, oregon connected a circumstantial effect of obesity specified arsenic precocious humor pressure.

"Our probe acceptable retired to link the dots. We person a ample cohort and a ample magnitude of data, truthful we tin qualify the links successful this group, showing however each alterations successful the obese organism are associated. The astir important facet of our enactment is showing these links," Correia-Lima said.

According to Simoes, it was the researchers' statistical investigation of the information that pointed to these links.

"Elevated levels of hormones specified arsenic insulin and leptin [the satiety hormone] whitethorn beryllium the origin of precocious humor pressure, for example," she said.

Simoes further said, "This benignant of accusation should beryllium taken into information erstwhile treating obesity. Physicians often prescribe anti-inflammatory drugs, which tin so mitigate 1 facet of the disease, but the attraction volition beryllium much implicit if you cognize astir different contributing factors."

Obesity is simply a multifactor disease, and attraction cannot beryllium one-size-fits-all. Diet and workout are important, but medicine whitethorn besides beryllium needed, arsenic good arsenic surgical involution and psychotherapy.

"Questionnaire-based assessments constituent to eating disorders astatine the intelligence level among these girls and boys. However overmuch we amusement that determination are alterations successful neuropeptides and hormones, arsenic good arsenic precocious humor pressure, inflammation and truthful on, yet the kid doesn't conscionable person an integrated occupation but a intelligence one," Simoes said.

"Hence the value of puerility obesity studies, to assistance aboriginal diagnosis and effort timely attraction earlier big complications acceptable in," Simoes concluded.

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