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Depression affects 10%-16% of pregnant women worldwide. Most get better with the help of antidepressant drugs. Although the safety of using antidepressants during pregnancy is endorsed by science, their effects on fetal neurodevelopment are poorly understood and should be studied with advanced techniques such as genomics. This is the main conclusion reached by a group of Brazilian researchers in a review of more than 100 scientific articles on fetal exposure to these drugs, especially [...]

Several factors increase the risk of heart attack, such as high blood sugar (hyperglycemia), obesity, abnormal cholesterol levels, high blood pressure (hypertension), and smoking. A study conducted in Brazil and reported in an article published in the journal PLOS ONE measured the impact of these factors. The researchers analyzed data for the Brazilian population collected between 2005 and 2017, determining the number of deaths attributed to each risk factor. The aim of the study was to [...]

Having shown that diet can influence gene expression, science is starting to find out more about how this happens. According to an article recently published in Food and Chemical Toxicology, a diet supplemented with or deficient in methionine, an essential amino acid abundant in eggs, meat and seafood, affects the expression of genes associated with liver cell fat metabolism and genes that modify chromatin, the coiled fibers made up of DNA and proteins that form chromosomes in cells. The [...]

Yellow fever is a non-contagious viral disease with two transmission cycles, sylvatic (in wild animals) and urban. Sylvatic yellow fever circulates among monkeys, and in Brazil is transmitted by mosquitoes of the genera Haemagogus and Sabethes, which bite an infected monkey and then infect others. Urban yellow fever circulates among humans and is transmitted by the mosquito Aedes aegypti (human-mosquito-human). Brazil has had no urban yellow fever cases since 1942, but [...]

Researchers from the University of São Paulo (USP) in Brazil have developed a strategy for treating the most aggressive type of brain cancer in adults that combines a photoactive molecule and a chemotherapeutic agent—both encapsulated in protein-lipid nanoparticles. Results of the research, supported by São Paulo Research Foundation—FAPESP, were presented during the FAPESP Week France symposium, by Antônio Claudio Tedesco, of the Center for Nanotechnology, [...]

Although neglected diseases account for 11 percent of the global disease burden, they are targeted by only a small proportion of the new drugs developed every year. Between January 2012 and September 2018, a total of 256 new drugs entered the market, but only eight (3.1 percent) were designed to treat neglected diseases. This value exceeds the proportion for 1975-99, which was 1.1 percent, but falls short of the 4.3 percent mark recorded for 2000-11. The term “neglected diseases” refers [...]