The Harvard Crimson

Harvard Scientists Find Stress Makes Hair Turn Gray

Publicado em 12 março 2020

Por Ethan Lee

A group of Harvard scientists and Brazilian researchers released a study Wednesday showing that hair pigmentation loss can be at least partly attributed to stress.

While initially conducting experiments on pain using mice, a team of Brazilian scientists affiliated with the Center for Research on Inflammatory Diseases made a surprising discovery – inducing pain upon the mice consistently caused their fur to turn white. Thiago Mattar Cunha, a researcher at the CRID, said in a press release that the team theorized stress was the key factor in these tests.

“We set out to check the hypothesis that the loss of fur color resulted from pain-induced stress,” Cunha said. “We designed a very simple experiment to see if the phenomenon was dependent on activation of sympathetic nerve fibers.”

Cunha — along with a group of scientists at Harvard who separately made the discovery — found that stress increases activity in the sympathetic nervous system, the network that controls the body’s “fight-or-flight” response to stress.

This process triggers melanocyte stem cells — which produce hair color — to undergo cell differentiation, the process by which stem cells can turn into other types of specialized cells. Because cell differentiation is permanent, this heightened activity depletes the supply of melanocytes, essentially leading to loss of hair pigmentation.

“We used various methodologies to show that intense sympathetic activity speeds up differentiation significantly,” Cunha said. “In our model, therefore, pain accelerated the aging of melanocyte stem cells.”

The research may pave the way for future studies into the physical impacts of stress, according to Ya-Chieh Hsu, the study’s senior author and a Stem Cell and Regenerative Biology professor at Harvard.

“Our discovery of the connection between the sympathetic nervous system and this stem cell population raises many questions about how stress might be affecting cell and tissue regeneration throughout the body,” Hsu wrote in an email to The Crimson. “It opens up many different avenues of research that we hope will lead to progress in addressing the health impacts of stress, and its potential connection with ageing [sic].”

For instance, Hsu wrote that she hopes the new findings will help researchers find a way to prevent negative impacts of stress — a problem for which there is no clear solution.

“One of our experimental validators had a protective effect in the mice we studied,” Hsu wrote. “However, I would like to also emphasize that there is still a long way from having an intervention for humans that is both safe and effective. Our study is the start of a long journey to discovering and developing interventions, but identifying the mechanism is always the key first step.”

The team plans to expand its research by working with peers in Cambridge to investigate other possible effects of stress.

“We have some exciting new collaborations planned with our colleagues within the Harvard, MIT, and [Harvard Stem Cell Institute] community, and we hope to look more deeply into the potential links between stress and other stem cells in the skin, as well as to explore interactions between nerves and stem cells in the skin,” Hsu wrote.

Essa notícia também repercutiu nos veículos:
TV Globo O Estado de S. Paulo Jornal da Cidade (Bauru, SP) Diário da Região (São José do Rio Preto, SP) online Estado de Minas UOL Estadã Veja online Folha de S. Paulo BOL UOL Diário do Grande ABC online Estado de Minas online BOL IstoÉ online IstoÉ Dinheiro online UOL Diário de Pernambuco online Correio Braziliense online TV Band Diário da Manhã (GO) Estado de Minas online Yahoo! Diário de Pernambuco online TV Cultura G1 UOL Veja online O Liberal (Americana, SP) Mundo Positivo Time 24 News (EUA) Terra BBC Brasil PCWorld Brasil SAPO Notícias (Moçambique) Smurphies Disco Club Terra Head Topics (Brasil) Farol da Bahia Noticias RTV (Espanha) Saúde Curiosa Blog Goiás DF Head Topics (Brasil) Central das Notícias MSN (Brasil) Blog do Valente VelhosAmigos Z1 Portal de Notícias Jornal Ação Popular Michel Teixeira Pleno.News Sobral 24 Horas Zero Hora online Diário do Pará online Belém online Portal da Band Central das Notícias Veja Saúde online Central das Notícias Folha Regional (Votuporanga, SP) online O Estado (MS) online Portal do Banzeiro Notícias ao Minuto (Portugal) Dica do tio Correio Popular (Campinas, SP) online Diário de Notícias online FasterNet A Crítica (MS) online A Província do Pará CGN Bem Paraná online Camocim Imparcial O Liberal (Americana, SP) online O Popular (Piracicaba, SP) online Mix Vale Meon Correio do Papagaio online Tribuna do Agreste Tribuna do Sertão Sistema Costa Norte de Comunicação Marechal News Portal do Holanda Repórter Diário Mais Goiás Tarobá News Aqui Notícias online RIC Mais Radar Santa Maria Portal do Holanda Tribuna do Cricaré online ClickPB Folha de Londrina online Central das Notícias DL News Informativo Em Foco Zero Hora online Manaus Alerta Mix Vale Rondônia Vip ES360 Atemporal W Rádio Brasil Piauí Noticias Central das Notícias Jornal Cidade (Porto Nacional, TO) online MSN (Portugal) Jornal da Manhã (Uberaba, MG) online ORC – Orlândia Rádio Clube Ltda – AM 1240 Khz Central das Notícias Afogados FM 87,9 Central das Notícias HiperNotícias FALA PARAÍBA Alhandra em Foco Bonde Meio Norte online (Piauí) O Povo online Espaço Ecológico no Ar Gazeta do Estado (Goiás) Jornal da Ciência online Sistema Costa Norte de Comunicação Sempre Família Marília Notícia Metro Jornal online Mix Vale Urgente News Sociedade Científica Portal da Enfermagem Boqnews Nativa News Rondônia em Pauta BCharts Correio de Carajás Folha do ABC online Central das Notícias Cidade Marketing New York Post (EUA) online The World News (EUA) Newzandar News India Times Post (Índia) Hot Celebrity reviews Monkey Viral (EUA) Worldwide News Today E health beauty tips Canaltech O Paraguaçu online Tech Na Net Córdoba Buenas Noticias (Espanha) Jornal da Franca Jornal da USP online Central das Notícias Saran Noticias e Variedades Genetic Engineering & Biotechnology News (EUA) Portal do Zacarias Jornal Correio do Norte (PR) online Portal do Governo do Estado de São Paulo Ata News Interdependente Os Cabeças da Notícia Mindzilla (Reino Unido) Max Notícias CBN Ribeirão Preto ES Capixaba Portal Banda B Correio do Povo (Porto Alegre, RS) online Clic Camaquã Idest Amazônia Brasil Rádio Web Planet Earth Water Air Green Brazil Região MS Notícias Paraíba Atual Rádio Nova FM Beto Ribeiro Repórter RD Foco Notícias Dom Total Universo Racionalista Estação Cereal Canal Gama Tribuna Ribeirão online Brazil Urgente Jornal Joseense News Central das Notícias DHoje Interior online Portal Paraná Empresarial Portal Brasil Empresarial Melody FM 94.1 Tribuna (Ribeirão Preto, SP) Clube FM 100.5 Band FM Tangará da Serra 92.1 106.7 FM (Ribeirão Preto, SP) ON Jornal Tribuna da Bahia Jornal Estação Jornal de Brasília Blog Popularizando Ciência Portal do Médico Blog Sempre Livre - Cristóvam Aguiar Revistanet SAPO Notícias (Angola) Blog Biólogo Padulla Jornal Portal R10 (PI) online Catraca Livre Diário do Planalto (Canoinhas, SC) online Litoral Hoje Blog Ultimas Noticias Ternura FM Head Topics (Brasil) Acontece Botucatu Agora MT Folha Vitória online Daynews ESHOJE (Vitória, ES) Cianorte em Destaque Centro de Bioética do CREMESP Is Life Corp Corriere Quotidiano (Itália) TV Assembleia - Assembleia Legislativa do Piauí (Alepi) Pn7 - Portal PaNoRaMa O Verdoso Innovare Mercado.ETC Band Gazeta de Alagoas online Correio da Amazônia Época Negócios online R7 Lifestyle HypeScience Alta Paulista News Jaru Online Portal Santa Izabel Instituto de Longevidade Mongeral Aegon Majestic Secretaria da Saúde do Estado de São Paulo Dra. Deborah Anna Duwe Pastor Jornal Startup Bem Cuidar Fest Pará Diário da Saúde Portal Thathi greenMe! Deutsche Welle (Alemanha) Correio do Brasil online Única Mania Blog Saúde Delivery Paulopes Pan Academia de Medicina Guanabara Koogan JMais Showmetech Porto Alegre 24 Horas Terra Portal Peperi Revista Revide online Revista Nova Família Viva a Longevidade Fatos Desconhecidos Fatos Desconhecidos Instituto Melo