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A study conducted in Brazil points to long-term functional abnormalities in their lungs two years after hospital discharge in most severe COVID-19 patients who had required intubation, and a return of pulmonary lesions after 24 months in some people who appeared to have fully recovered on being discharged. The study involved 237 patients admitted to Hospital das Clínicas, a hospital complex run by the University of São Paulo's Medical School (FM-USP), between March and [...]

Already at the beginning of the COVID-19 pandemic, a group of Brazilian researchers pioneered in showing why SARS-CoV-2 infection tends to be more severe in diabetic patients. Now, the same team based at the Institute of Biology of the State University of Campinas (IB-UNICAMP) has discovered one of the reasons why obese people who do not have diabetes or even insulin resistance also have an increased risk of developing the severe form of the disease. “New experiments show that the [...]

Researchers at the University of São Paulo (USP) in Brazil have shown for the first time that SARS-CoV-2, the virus that causes COVID-19, can remain in the sperm of patients for up to 90 days after hospital discharge and up to 110 days after the initial infection, reducing semen quality. The study is reported in an article published in the journal Andrology. The authors suggest that people who plan to have children should observe a period of “quarantine” after [...]

A major bivalent COVID-19 vaccine induces production of neutralizing antibodies against the coronavirus that circulated at the start of the pandemic as well as subvariants of omicron, albeit less abundantly, according to a Brazilian study reported in the Journal of Medical Virology. The study confirmed the vaccine’s effectiveness and its importance to control of the disease, while also showing that, more than three years after the first application of a COVID-19 vaccine in Brazil, the [...]

The chikungunya virus, transmitted by Aedes aegypti and Aedes albopictus mosquitoes and responsible for more than 900 deaths in Brazil since it arrived around ten years ago, is capable of spreading through the blood, reaching multiple organs and crossing the blood-brain barrier, which protects the central nervous system. The mechanisms of action observed for the first time in fatal cases by a group of Brazilian, American and British researchers are reported in an article published in Cell [...]

Offspring of rats that consume excessive amounts of fructose develop disturbances in the autonomic nervous, cardiovascular, and metabolic systems at an early age, increasing the risk of chronic diseases such as diabetes and obesity in adulthood, according to a study conducted by Brazilian scientists. The study is published in the International Journal of Obesity. The findings confirm information in the scientific literature regarding the appearance of metabolic disorders such as high levels [...]

Introduction Tuberculosis (TB) is a highly infectious disease caused by the bacterium Mycobacterium tuberculosis. It primarily affects the lungs but can also affect other parts of the body. According to the World Health Organization (WHO), TB is one of the top 10 causes of death worldwide, with an estimated 10 million people falling ill with the disease in 2019 alone. The Study A recent study conducted by University of São Paulo has shed light on a mechanism that aggravates [...]

A study conducted at the University of São Paulo helps explain why older people are more susceptible to the severe form of the disease and why it involves blood clotting disorders. An article published in NPJ Aging, a Springer Nature journal, reveals that natural production of auto-antibodies increases with age and that infection by SARS-CoV-2 can exacerbate production of auto-antibodies relating to auto-immune diseases, helping to explain why aging increases the [...]

Research conducted at the University of São Paulo (USP) in Brazil shows that SARS-CoV-2, the virus that causes COVID-19, can infect liver cells (hepatocytes), stimulating glucose production and leading to a condition similar to diabetes (hyperglycemia) in hospitalized patients, even if their blood sugar level was normal before they were admitted to hospital. An article on the study is published in Proceedings of the National Academy of Sciences (PNAS). The findings describe part of [...]