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Researchers at the Federal University of São Carlos (UFSCar) in the state of São Paulo, Brazil, in partnership with colleagues at University College London in the UK have discovered an efficient, simple and inexpensive method of predicting the risk of functional disability in older people. They analyzed data from more than 3,000 over-sixties living in England and found that slowness of gait alone can be considered a predictor of loss of the capacity to perform the basic and [...]

Researchers at the University of São Paulo (USP) in Brazil have shown that a hypertonic saline solution inhibits replication of SARS-CoV-2, the virus that causes COVID-19, and have elucidated the biochemical mechanism involved. An article reporting the research is published in ACS Pharmacology & Translational Science. The study was performed in the laboratory using human epithelial lung cells infected with the virus. If the strategy proves effective in clinical trials, it could [...]

Common blood-pressure drugs may improve survival for patients with colorectal cancer, a new study suggests. After reviewing outcomes of almost 14,000 patients with colorectal cancer, researchers determined that ACE inhibitors, beta-blockers and thiazide diuretics were all associated with decreased mortality. They also found that patients who took their blood-pressure drugs consistently were less likely to die from their cancer. The researchers emphasize that more research is needed to [...]

The presence of pro-inflammatory cytokines in the blood can boost the effects of daily cannabis use and heighten the risk of developing psychosis in adulthood. Similar results have been observed, also in the presence of cytokines, when cannabis is used during adolescence. Psychotic disorders include symptoms such as delirium, loss of a sense of reality, hallucinations, hearing voices, and cognitive and social impairments. A study by researchers at the University of São Paulo’s [...]

Quality of life relating to physical and mental health can be a key element in the treatment of obese adults. For this reason, interdisciplinary clinical measures including cognitive and behavioral therapy may produce more significant outcomes for these people, reducing not just weight but also symptoms of depression. This is the main conclusion of a study conducted in Brazil by the Obesity Research Group at the Federal University of São Paulo (UNIFESP) in Santos, São Paulo [...]

Researchers have succeeded in revealing the arsenal used by protozoans of the genus Leishmania in human cells to make leishmaniasis more severe, especially in cases of the mucocutaneous variety of the disease, which can cause deformations in patients. The discovery points the way to a search for novel treatments for the disease as well as casting light on a key mechanism involved in other diseases. The mechanism involves Leishmania, macrophages and a virus that lives endosymbiotically in the [...]

In a study aimed at investigating the mechanism responsible for exacerbating rheumatoid arthritis in smokers, researchers at the Center for Research on Inflammatory Diseases (CRID), linked to the University of São Paulo (USP) in Brazil, discovered a novel path in the inflammatory process associated with the bone damage caused by rheumatoid arthritis. The discovery opens up opportunities for new therapeutic interventions to mitigate the effects of the disease, for which there is no [...]

Tityus serrulatus, the Yellow scorpion, causes more deaths than any other venomous animal in Brazil. Its sting can induce heart attack and pulmonary edema, especially in children and the elderly. According to the Brazilian Health Ministry, more than 156,000 cases of scorpion envenomation, 169 fatal, were reported in the country in 2019. Researchers at the University of São Paulo (USP) have demonstrated for the first time that in severe cases of scorpion envenomation a systemic [...]

Shortly after the explosion in microcephaly cases caused by Zika virus in Brazil in 2015-16, several scientific studies were published with evidence that the pathogen is capable of crossing the human placenta, the organ that keeps the fetus connected to the mother’s body during pregnancy. From then on, the states began following a protocol established by the National Ministry of Health requiring collection of placental samples to help diagnose the disease in women with symptoms during [...]