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Global DNA Damage Response Targeting Therapeutics Market Report 2021: Current Landscape and the Likely Adoption of DNA Damage Response Targeting Therapeutics in Healthcare Over the Next Decade

Publicado em 06 outubro 2021



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6 October 2021, 6:23 am · 7-min read

Dublin, Oct. 06, 2021 (GLOBE NEWSWIRE) -- The "DNA Damage Response Targeting Therapeutics Market by Target Disease Indication, Therapeutic Area, Target Molecule, Type of Molecule, Route of Administration, and by Key Geographical Regions: Industry Trends and Global Forecasts, 2021-2030" report has been added to's offering.

The DNA Damage Response Targeting Therapeutics (beyond PARP inhibitors) Market report features an extensive study of the current landscape, offering an informed opinion on the likely adoption of DNA damage response targeting therapeutics in the healthcare industry, over the next decade. The report features an in-depth analysis, highlighting the capabilities of various stakeholders engaged in this domain.

Currently, there are four approved poly-ADP ribose polymerase (PARP) inhibitor drugs that are based on the inhibition of the DNA damage repair process in advanced stage oncological indications. Further, drug developers across the world, claim to be evaluating several other molecular targets, such as ATM, ATR, CHK1, and WEE1, within the DNA damage response pathway.

Although majority of the drug candidates for molecular targets (other than PARP) are in the preclinical / initial clinical stages, drug developers are optimistic regarding the therapeutic potential of this emerging class of drugs. Gradually, a substantial body of evidence, validating the efficacy of drugging the aforementioned biological targets, is being generated through extensive research in this field; this is reflected in the rapidly growing number of research publications and patents focused on this subject.

Driven by encouraging clinical trial results, this niche, but upcoming market, is poised to witness healthy growth over the next decade, with pioneers in the field likely to benefit from the first-to-market advantage.

One of the key objectives of the report was to estimate the existing market size and future opportunity for DNA damage response targeting therapeutics developers, over the next decade. Further, we have provided an informed estimate of the evolution of the market, during the period 2021-2030, based on several relevant parameters, such as adoption trends, and expected price variations for these products.

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Amongst other elements, the report includes:

A detailed review of the current market landscape of DNA damage response targeting therapeutics, including information on phase of development (clinical and preclinical), target disease indication(s), therapeutic area (hematological malignancies, immune-oncological disorders, neurological disorders, solid tumors, unspecified oncological disorders, and other disorders), target molecule, type of molecule (biological and small molecules), type of therapy (monotherapies, and combination therapies), dosage form (solid, and liquid), route of administration (intravenous, subcutaneous, and oral), and special drug designation awarded (if any). In addition, it highlights the companies engaged in the development of DNA damage response targeting therapeutics, along with information on their year of establishment, company size (in terms of employee count) and location of respective headquarters.

An in-depth analysis of the contemporary market trends, presented using four schematic representations, including [A] a bubble analysis comparing the leading players engaged in this domain, based on several relevant parameters (such as product portfolio strength, phase of development and company size), [B] an insightful tree map representation of DNA damage response targeting therapeutics developers, based on their target therapeutic area and company size, [C] a world map representation highlighting the regional distribution of developers engaged in this domain, and [D] a grid representation illustrating the distribution of DNA damage response targeting therapeutics based on their phase of development, target therapeutic area, type of molecule, type of therapy, and route of administration.

Elaborate profiles of prominent players engaged in the development of DNA damage response targeting therapeutics. Each profile features a brief overview of the company, details related to its respective drug candidates, recent developments and an informed future outlook.

A detailed analysis of more than 250 completed, ongoing and planned clinical studies of various DNA damage response targeting therapeutics, based on several relevant parameters, such as trial registration year, number of patients enrolled, gender of patients enrolled, trial phase, recruitment status and study design, highlighting leading sponsors / collaborators and leading players (in terms of number of trials conducted), type of organization, popular therapeutic areas and regional distribution of trials. In addition, it features an insightful case study (for trials related to clinical DNA damage response targeting therapeutics, within the scope of the report).

An analysis of more than 150 peer-reviewed scientific articles related to DNA damage response targeting therapeutics, published during the period April 2020 to March 2021, highlighting the research focus within this niche industry segment. Additionally, it features an informed opinion on the key trends observed across the aforementioned publications, including information on target disease indications, and analysis based on several relevant parameters, such as year of publication, type of publication, key research hubs, most popular authors, provision of grant awarded, target molecule, and most popular journals (in terms of number of articles published in the given time period and journal impact factor). Further, it includes a multivariate publication attractiveness analysis based on various parameters, such as type of publication, grant support, journal impact factor, and number of target molecules under study.

An insightful multivariate scenario management analysis impacting adoption rates and price points taking into consideration more than 20 parameters.

Additionally, the report features the likely distribution of the current and forecasted opportunity within DNA damage response targeting therapeutics market across

Target disease indications (acute myeloid leukemias, COVID-19, diabetic macular edemas, mesotheliomas, myelodysplastic syndromes, non-squamous non-small cell lung cancers, prostate cancers, and uterine serous carcinomas)

Therapeutic areas (hematological malignancies, solid tumors, and other disorders)

Target molecule (APE/REF-1, casein kinase 2, CHK-1, C-Tak, DHODH, MAPKAPK2, p53, and WEE 1)

Type of molecule (biologics and small molecule)

Route of administration (oral drugs and intravenous drugs)

Key geographical regions (US, Canada, Denmark, France, Germany, Italy, Spain, UK, Australia, Singapore, and South Korea).

Key Questions Answered

Who are the leading players engaged in the development of DNA damage response targeting therapeutics?

Which popular molecules are being targeted by DNA damage response targeting therapeutics?

Which companies are actively involved in conducting clinical trials for their therapeutics?

What is the evolving trend related to the focus of publications related to DNA damage response targeting therapeutics?

What are key factors impacting the pricing and adoption of DNA damage response targeting therapeutics?

What opportunities are available for DNA damage response targeting therapeutics in emerging markets?

How is the current and future opportunity likely to be distributed across key market segments?

Companies Mentioned


Agios Pharmaceuticals

Allarity Therapeutics

Ankrin Therapeutics

Apexian Pharmaceuticals

ApoGen Biotechnologies

Aprea Therapeutics

Aptose Biosciences

Artios Pharma

Aslan Pharmaceuticals


Atrin Pharmaceuticals


BDC Capital


Breakpoint Therapeutics

Bristol Myers Squibb

BVF Partners


Cancer Research UK

Canadian Institutes of Health Research (CIHR)

China Scholarship Council

Chordia Therapeutics


Cowen Healthcare Investments

Cybrexa Therapeutics

Cyclacel Pharmaceuticals

Cyteir Therapeutics

Daiichi Sankyo


Deutsche Forschungsgemeinschaft

EMD Serono


Fonds de solidarite FTQ

FoRx Therapeutics

Grant Agency of the Slovak Republic

Health Effects Institute


The United States Department of Health and Human Services (HHS)

IDEAYA Biosciences

Impact Therapeutics

Ministry of Science and Innovation of Spain

Innovative Genomics Institute (IGI)


Karolinska Development

Kazan Federal University

Kinnate Biopharma

Kyoto University Innovation Capital

Lixte Biotechnology

Logos Capital


Merck KGaA

Ministry of Science and ICT

Mission Therapeutics

Massachusetts Institute of Technology (MIT)

Mitsubishi UFJ Capital

MPM Capital

National Institutes of Health (NIH)

National Institute of Allergy and Infectious Diseases (NIAID)

National Institute of General Medical Sciences

National Natural Science Foundation of China (NSFC)

National Research Foundation of Korea (NRF)

National Science Center

Natural Science Foundation of Inner Mongolia


ONO Pharmaceutical



Orchard Therapeutics





Rain Therapeutics


Repare Therapeutics

Rock Springs Capital

5AM Ventures

Rocket Pharmaceuticals

Sao Paulo Research Foundation (FAPESP)

University of Texas MD Anderson Cancer Center

Sectoral Asset Management

Senhwa Biosciences

Shinsei Capital Partners

Sierra Oncology

SMBC Venture Capital


Tarveda Therapeutics

Tempest Therapeutics

TRACON Pharmaceuticals

Triplet Therapeutics


Versant Ventures

Vertex Pharmaceuticals

Swedish Research Council

Zentalis Pharmaceuticals

For more information about this report visit

CONTACT: CONTACT: Laura Wood, Senior Press Manager For E.S.T Office Hours Call 1-917-300-0470 For U.S./CAN Toll Free Call 1-800-526-8630 For GMT Office Hours Call +353-1-416-8900


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