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Some researchers are racing against time to uncover the unknown diversity in nature, while also developing ways to save it. Fungi are among the most diverse and ecologically important kingdoms in life. Now, a group from the University of Jyväskylä in Finland is focused on mapping fungi, and is using the air to do it. The researchers noted, “To provide an integrated view of the spatial and seasonal dynamics of fungi, we implemented a globally distributed standardized aerial [...]

Terragia Biofuel raised $6 million in a seed round led by Engine Ventures and Energy Impact Partners. Terragia officials say the company will use the capital to commercialize its biology-based approach to converting cellulosic biomass into ethanol and other products, expand its employee headcount, and initiate partnerships with major biofuel producers. Terragia uses engineered thermophilic bacteria to break down cellulosic biomass and convert it into ethanol and other chemical products. The [...]

RNA-based immunizing agents have enriched the repertoire of technologies used for vaccine development. An analysis of the active clinical trials in early Phase I and Phase I during the year of 2023 illustrates this point. A total of 161 active vaccine trials were registered at clinicaltrials.gov. Information from these trials was used to plot (Chart 1) and (Chart 2) SARS-CoV-2/COVID-19 trials were excluded to give more evidence to other disease targets. The highest number of trials were [...]

By Denise Golgher, PhD, and Robert Rodrigues Four years ago, we wrote about biomedical innovation in Brazil. Human health digital technologies and molecular diagnostics were described as the major drivers of innovation in the country. Meanwhile, diagnostic companies and private research hospitals were considered protagonists of a complex ecosystem. However, as the COVID-19 pandemic hit, the health care system changed, and new research is of utmost relevance. Since COVID-19, health [...]

Scientists at the University of California, San Diego (UCSD), School of Medicine used human brain organoids to reveal how a genetic mutation associated with a profound form of autism disrupts neural development. Using gene therapy tools to recover the gene’s function effectively rescued neural structure and function. Their study is published in Nature Communications, in a paper titled, “Transcription Factor 4 loss-of-function is associated with deficits in progenitor [...]

Vaccines can be made more than 25% more effective by adding left-handed chiral gold nanoparticles as adjuvants, according to the results of a study by an international research team in China, the United States, and Brazil. In a publication in Nature, the researchers reported the results of tests with their nanoparticles on human immune cells and also in combination with a vaccine against the influenza virus. “The key to understanding the contribution of these nanoparticles is the concept [...]

Research by scientists at the University of Campinas (UNICAMP) in Brazil has demonstrated how treatment using an antibacterial drug can boost metabolism and attenuate weight gain induced by a fatty diet in experimental mice. The studies, headed by Marcelo Mori, PhD, a professor at the university’s Biology Institute (IB-UNICAMP), showed that treatment with the broad-spectrum fluoroquinolone antibiotic enoxacin, triggered the animals’ white adipose tissue (WAT)—which normally [...]

Researchers in Brazil have identified a group of co-expressed genes that are dysregulated in induced pluripotent stem cell (iPSC)-derived neuronal cells from patients with autism spectrum disorder (ASD), and which could potentially be used as a biomarker or even therapeutic target for the neurodevelopmental disorder. The study results, reported by scientists at the University of São Paulo’s Institute of Biosciences (IB-USP), indicate that a common gene expression profile my [...]

Scientists at São Paulo State University (UNESP) in Brazil, along with colleagues from the University of Southern Denmark, and the University of Antioquia’s Medical School in Colombia, say they have analyzed 12 types of cancer and identified patterns of tumor protein secretion that correlated with the prevalence of cachexia and average weight loss for each type. Their study “ The expression landscape of cachexia-inducing factors in human cancers ,” appears in the [...]