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The process of cellular aging is multifactorial, and its investigation involves several knowledge areas. Finding ways to protect cells against damage is a key focus. A group of researchers recently achieved noteworthy progress in this regard, as evidenced by an article published in Scientific Reports. According to the authors, in their study, the protein klotho protected glial cells against inflammation and death. Glia are non-neuronal cells of the brain and nervous system. There are several [...]

Researchers at the University of São Paulo (USP) in Brazil analyzed data from 43 scientific articles describing the effects of COVID-19 on athletes and concluded that while the disease was asymptomatic or mild in the vast majority of cases (94%), about 8% of the subjects concerned had persistent symptoms affecting their performance and potentially preventing a return to training and competing. The data they analyzed referred to some 11,500 athletes, including amateurs and [...]

The COVID-19 pandemic has changed the way people perceive the passage of time, according to an article published in the journal Science Advances. At the end of the first month of social distancing, in May 2020, most participants in the study (65%) reported feeling time was passing more slowly. The researchers classified this perception as “time expansion” and found it to be associated with feelings of loneliness and a lack of positive experiences in the period. An even [...]

In a study published May 02, 2022 in Nature Communications, scientists at University of California San Diego School of Medicine used human brain organoids to reveal how a genetic mutation associated with a profound form of autism disrupts neural development. Using gene therapy tools to recover the gene’s function effectively rescued neural structure and function. Several neurological and neuropsychiatric diseases, including autism spectrum disorders (ASD) and schizophrenia have been [...]

Omicron emerged as a variant of concern only in November 2021, but all the mutations it contains except one had been described before that. Researchers at the Federal University of São Paulo (UNIFESP) in Brazil, supported by FAPESP, attribute this factor to the effectiveness of the existing vaccines against the variant, reflected in the relatively small number of severe cases and deaths despite Omicron’s heightened transmissibility. The hypothesis is raised in an article by [...]

A study conducted at the University of São Paulo (USP) in Brazil suggests people previously infected by Chikungunya virus may develop partial immunity to Mayaro virus. The finding, presented in Journal of Virology, is based on experiments involving mice and blood serum from patients. According to the authors, this type of cross-protection may be one of the reasons for the absence of a major outbreak of Mayaro fever in Brazil. The study was supported by FAPESP.  In the [...]

Researchers who analyzed data for São Paulo state, Brazil, found the highest rates of newborn mortality from asphyxia in cities in the south, southeast and north of the state between 2004 and 2013. They cross-tabulated these results with economic data and detected a combination of high mortality with low per capita gross domestic product (GDP) in 31 of the cities. Neonatal asphyxia correlates highly with low-quality antenatal and postpartum care. These are the main findings of a study [...]

An article published in Frontiers in Immunology suggests that sepsis can cause alterations in the functioning of defense cells that persist even after the patient is discharged from hospital. This cellular reprogramming creates a disorder the authors call post-sepsis syndrome, whose symptoms include frequent reinfections, cardiovascular alterations, cognitive disabilities, declining physical functions, and poor quality of life. The phenomenon explains why so many patients who survive sepsis die [...]