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Oral health deteriorates in morbidly obese people on a diet in preparation for bariatric surgery and patients who have undergone the procedure, with increasing caries, gingivitis and periodontitis. This is the conclusion of a study conducted by researchers at the Federal University of São Paulo (UNIFESP) in Brazil. Articles on the study are published in the Journal of Oral Rehabilitation and Clinical Oral Investigations, stressing the importance of participation by a dentist in the [...]

Resistance to antibiotics is a problem that alarms the medical and scientific community. Bacteria resistant to three different classes of antibiotics, known as multi-drug resistant (MDR) bacteria, are far from rare. Some are even resistant to all currently available treatments and are known as pan-drug resistant (PDR). They are associated with dangerous infections and listed by the World Health Organization (WHO) as priority pathogens for drug development with maximum urgency. An article [...]

A drug carrier able to reach the brain, bind to an aggressive type of tumor called glioblastoma multiforme, and release a chemotherapeutic agent has been tested for the first time by Brazilian researchers. According to an article published in the International Journal of Pharmaceutics, the potential treatment was shown to be effective in isolated cells and animal models thanks to a combination of nanotechnology, chemotherapy and a monoclonal antibody. Glioblastoma multiforme accounts for 60% [...]

What does science know about the relationship between physical activity and COVID-19, and what still needs to be investigated? Bruno Gualano, a professor at the University of São Paulo’s Medical School (FM-USP) in Brazil, answers these two questions in an editorial published recently in the British Journal of Sports Medicine. “As speculated at the start of the pandemic and now consistently proven, physically active people tend to experience a milder [...]

Researchers who analyzed data for São Paulo state, Brazil, found the highest rates of newborn mortality from asphyxia in cities in the south, southeast and north of the state between 2004 and 2013. They cross-tabulated these results with economic data and detected a combination of high mortality with low per capita gross domestic product (GDP) in 31 of the cities. Neonatal asphyxia correlates highly with low-quality antenatal and postpartum care. These are the main findings of a study [...]

Brazilian and U.S. researchers have developed a molecule called FRW that proved capable of binding to blood vessels in the brain but not in other organs when injected into the bloodstream in tests with mice. They used the technique to produce the first ever complete map of the vasculature of the brain, paving the way for the creation of novel diagnostic imaging strategies and therapies for diseases such as Alzheimer’s and Parkinson’s. The research was supported by São Paulo [...]

Dysregulation of the signaling pathway known as the beta-catenin-dependent Wnt can also cause embryo malformation and contribute for the development of breast and cervical cancer.